Takanori Kin

Clinical implications of serum GDF15 propeptide as a biomarker for bone metastasis across common solid tumors: a real-world multi-institutional study

Gaku Yamamichi, Taigo Kato, Atsuki Matsukawa, Nanae Masunaga et autres

Bone metastasis (BM) frequently occurs in various types of cancer, particularly in prostate (PCa), breast (BCa), renal (RCC), and lung cancers (LCa), yet no reliable biomarker has been established. In this study, we evaluated the clinical utility of serum growth differentiation factor …

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Analysis of PIK3CA mutations in the lysate of sentinel lymph nodes in patients with early breast cancer

Sung Ae Park, Nanae Masunaga, Takanori Kin, Ryu Tokui et autres

Background Although one-step nucleic acid amplification (OSNA), which measures cytokeratin (CK) 19 mRNA copies, is used for intraoperative detection of sentinel lymph node (SN) metastasis, CK19 mRNA copy number may not always accurately reflect total tumor load in the SN. Because number …

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Impact of using intraoperative nomograms with one-step nucleic acid amplification to omit axillary lymph node dissection in patients with breast cancer who underwent mastectomy

Takanori Kin, Nanae Masunaga, Chieko Mishima, Masami Tsukabe et autres

BACKGROUND: Omission of axillary lymph node dissection (ALND) in patients with positive sentinel lymph nodes (SLN) who underwent mastectomy remains controversial. In this study, we reported the omission of ALND in mastectomy cases with positive SLNs, using a nomogram to predict non-SLN …

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Roles of Tumor-Infiltrating Lymphocytes and Antitumor Immune Responses as Predictive and Prognostic Markers in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy

Ryungsa Kim, Takanori Kin, Koji Arihiro

Tumor-infiltrating lymphocytes (TILs) are thought to play important roles in tumor shrinkage and survival prolongation in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). TILs are mononuclear immune cells such as lymphocytes and plasma cells, including CD4+ and CD8+ T cells, natural …

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Impact of Using Intraoperative Nomograms with One-Step Nucleic Acid Amplification to Omit Axillary Lymph Node Dissection in Patients with Breast Cancer Who Underwent Mastectomy

Takanori Kin, Nanae Masunaga, Kaori Abe, Chieko Mishima et autres

Accumulation of CD56+ CD16- Natural Killer Cells in Response to Preoperative Chemotherapy for Breast Cancer

Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Mika Shimoyama et autres

Background: The activation of the antitumor immune responses of T cells and natural killer (NK) cells is important to induce breast tumor shrinkage via preoperative chemotherapy. We evaluated how antitumor immune responses contribute to the effects of such therapy. Methods: Forty-three patients …

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Baseline gut microbiota as a predictive marker for the efficacy of neoadjuvant chemotherapy in patients with early breast cancer: a multicenter prospective cohort study in the Setouchi Breast Project-14

Shogo Nakamoto, Yukiko Kajiwara, Kohei Taniguchi, Akira I. Hida et autres

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Impact of Complex Apoptotic Signaling Pathways on Cancer Cell Sensitivity to Therapy

Ryungsa Kim, Takanori Kin, William T. Beck

Anticancer drugs induce apoptotic and non-apoptotic cell death in various cancer types. The signaling pathways for anticancer drug-induced apoptotic cell death have been shown to differ between drug-sensitive and drug-resistant cells. In atypical multidrug-resistant leukemia cells, the c-Jun/activator protein 1 (AP-1)/p53 signaling …

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Outcomes in patients with non‐invasive breast carcinoma

Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Mika Shimoyama et autres

BACKGROUND AND AIM: Non-invasive breast carcinoma is considered to be localized disease and is distinguished from invasive ductal and lobular carcinomas. The local recurrence of non-invasive carcinoma after surgery may lead to development of invasive carcinoma and promote distant metastasis, which worsens …

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Breast cancer recurrence and survival rates in patients who underwent breast‐conserving surgery under non‐mechanically ventilated anesthesia

Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Mika Shimoyama et autres

BACKGROUND: Recurrence after primary treatment is an important obstacle to the curing of primary breast cancer. Less-immunosuppressive anesthetic techniques, such as local anesthesia with lidocaine, intravenous anesthesia (IVA) with propofol, and/or sedation with midazolam under spontaneous breathing may reduce breast cancer recurrence …

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Current Status and Prospects of Anesthesia and Breast Cancer: Does Anesthetic Technique Affect Recurrence and Survival Rates in Breast Cancer Surgery?

Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Takanori Kin

The relationship between the anesthetic technique and cancer recurrence has not yet been clarified in cancer surgery. Surgical stress and inhalation anesthesia suppress cell-mediated immunity (CMI), whereas intravenous (IV) anesthesia with propofol and regional anesthesia (RA) are known to be protective for …

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Current and Future Therapies for Immunogenic Cell Death and Related Molecules to Potentially Cure Primary Breast Cancer

Ryungsa Kim, Takanori Kin

How primary breast cancer can be cured after (neo)adjuvant therapy remains unclear at the molecular level. Immune activation by anticancer agents may contribute to residual tumor cell eradication with postsurgical (neo)adjuvant chemotherapy. Chemotherapy-induced immunogenic cell death (ICD) may result in long-term immune …

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