William M. Grady

Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression

Ming Yu, Yumo Xie, Lena Allen, Kelly Carter et autres

Abstract Colorectal cancer develops through a normal-adenoma-carcinoma sequence, yet only 5-10% of adenomas progress to malignancy, and the cellular programs governing that sequence remain poorly defined. Here we generate a spatial multi-omics atlas of human colon adenomas, combining Visium CytAssist and protein …

Afrique du Sud, us (code pays fourni par la source)

Abstract 2867: Interaction between T-cell inflamed gene expression profile score and tumor-associated microbiome on colorectal cancer mortality in a heterogeneous patient population

Claire E. Thomas, Hang Yin, Jeroen R. Huyghe, Nicole Catalina Loroña et autres

Abstract Background: The microbiome and tumor immune response are important and inter-related components that are implicated in colorectal cancer (CRC) prognosis. However, associations between these components and potential joint effects on CRC mortality remain unclear. Methods: We included 366 participants with CRC …

us (code pays fourni par la source)

Abstract PR015: Multidimensional assessment of toxicities and survivorship among people with early-onset colorectal cancer – Results from the ColoCare Study

Jane C. Figueiredo, Nicole C. Loroña, Anne Kirchoff, Karely V T. Van Thiel Berghuijs et autres

Abstract Background: In 2024, colorectal cancer (CRC) emerged as the leading cause of cancer death in men under 50 and the second leading cause in women (referred to as early-onset CRC (EOCRC). The incidence of EOCRC is growing by 1.4% annually. Understanding …

us, de, Afrique du Sud (code pays fourni par la source)

Data from Methylation Subtypes of Primary Prostate Cancer Predict Poor Prognosis

Xiaoyu Wang, Kristina M. Jordahl, Chenghao Zhu, Julie Livingstone et autres

AbstractBackground: Patients with prostate cancer experience heterogeneous outcomes after radical prostatectomy. Genomic studies including The Cancer Genome Atlas (TCGA) have reported molecular signatures of prostate cancer, but few studies have assessed the prognostic effects of DNA methylation profiles. Methods: We conducted the …

Supplemental Table 1 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 1: Primer/probe sequences used in the duplex mEVL assay

Supplemental Figure 1 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Figure 1. Flowchart of patient selection. * Subjects with hereditary conditions or inflammatory bowel disease (IBD) were excluded. A flowchart showing the selection process for the subjects included in the studies is shown. The primary exclusion criteria that affected subject selection …

Supplemental Figure 4 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Figure 4: Methylation levels of normal colon for patients with no history of adenoma or cancer after initial amongst those at least 4 years of follow-up (left group) and levels for patients with an adenoma or colorectal cancer detected after initial …

Supplemental Table 2 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 2: Summary patient characteristics for Comparison Set 1

Supplemental Table 4 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 4: Summary patient characteristics for Comparison Set 3

Supplemental Table 3 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 3: Summary patient characteristics for Comparison Set 2

Supplemental Table 5 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 5: Summary statistics for methylated EVL measurements in Comparison Set 1

Supplemental Table 6 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas

Ming Yu, Kelly Carter, Kelsey K. Baker, Mary W. Redman et autres

Supplemental Table 6: Summary statistics for methylated EVL measurements in Comparison Set 2