Lars A. Akslen

Tumor cell proliferation by mitotic count and Ki67 in prognostication and subclassification of hormone receptor-positive breast cancer

Gøril Knutsvik, Ingunn M. Stefansson, Sura M. Aziz, Tor Audun Klingen et autres

Abstract Purpose Mitotic count (MC) and Ki67 expression are well-known prognostic factors in breast cancer. Whereas MC is part of histologic grade but not always reported separately, Ki67 is hampered by lack of methodological standardization. Our aim was to assess how proliferation …

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Imaging mass cytometry data from: Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer

Kenneth Finne, Silje Kjølle, Magdalena Ríos-Romero, Even Birkeland et autres

This record contains raw imaging mass cytometry data related to article "Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer" AbstractBreast cancers are biologically and clinically diverse. While large-scale gene expression analyses have enabled epithelial-centered molecular classifications, studies of the tumor …

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Imaging mass cytometry data from: Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer

Kenneth Finne, Silje Kjølle, Magdalena Ríos-Romero, Even Birkeland et autres

This record contains raw imaging mass cytometry data related to article "Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer" AbstractBreast cancers are biologically and clinically diverse. While large-scale gene expression analyses have enabled epithelial-centered molecular classifications, studies of the tumor …

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Stromal-based proteome data improve stratification of hormone receptor-positive breast cancer

Kenneth Finne, Silje Kjølle, Magdalena Ríos Romero, Even Birkeland et autres

Breast cancers are biologically and clinically diverse. While large-scale gene expression analyses have enabled epithelial-centered molecular classifications, studies of the tumor microenvironment (TME) remain limited, especially at the proteome level using tissue-specific resolution. By laser capture microdissection and mass spectrometry-based proteomics followed …

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Abstract 720: Nerve innervation in solid tumors.

Hui Yu, Aglaia Schiza, Victor Pontén, Viktoria Thurfjell et autres

Abstract The role of nerve innervation in cancer progression remains highly debated. While various in vitro and in vivo models suggest that tumor cells can actively induce neoneurogenesis, tissue-based evidence remains sparse. In this project, we critically examine the hypothesis of tumor-associated …

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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Luka Tandarić, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen et autres

The limited efficacy of immunotherapy in clinical trials in high-grade serous ovarian cancer (HGSOC) may improve by implementing experimental models that are more reflective of human biology into preclinical studies. To address this, we developed and validated a humanized patient-derived xenograft mouse …

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Establishment of a humanized patient-derived xenograft mouse model of high-grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Luka Tandarić, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen et autres

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Low-Cost Lung Cancer Classification in WSIs Using a Foundation Model and Evolving Prototypes

Soroush Oskouei, André Pedersen, Marit Valla, Vibeke Grotnes Dale et autres

Whole slide imaging has transformed the field of pathology by enabling high-resolution digitization of histopathological slides. However, the large image size and variability in morphology, tissue processing, and imaging can pose challenges for robust computational analysis. When working with specific tasks in …

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Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival

Astrid A. Syrtveit, Lise Martine Ingebriktsen, Amalie F. Tegnander, Lars A. Akslen et autres

In the growing tumor, hypoxia may lead to tumor necrosis which is associated with more aggressive tumor features and reduced patient survival. However, there are shortcomings in our understanding of biological features and clinical significance linked to tumor necrosis. We therefore analyzed …

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Andreas Olav Holsen Myking

Bjørn Inge Bertelsen, Lars A. Akslen, Sverre Jarl Mørk, Elisabeth Wik et autres

Foto: Tor Christensen /

Reduced GATA3 expression associates with immuno‐metabolic alterations and aggressive features in breast cancer

Anna Kristine Myrmel Sæle, Amalie A. Svanøe, Cecilie Askeland, Gøril Knutsvik et autres

In breast cancer (BC), the transcription factor GATA3 is linked to estrogen receptor (ER) alpha biology, and its loss is associated with aggressive tumor features. Little is reported about potential roles and implications of GATA3 independent of ER, and possible relationships to …

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Adrenergic signals influence proteomic responses in breast cancer cells

Manuel Carrasco, Ole Vidhammer Bjørnstad, Heidrun Vethe, Lars A. Akslen

Introduction: Breast cancer remains a major health challenge due to its molecular heterogeneity and complex interactions with the tumor microenvironment. Adrenergic signaling, mediated by stress hormones such as noradrenaline, has emerged as a potential regulator of cancer progression, influencing cell proliferation, cell …

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