Gertrud Laura Sørensen

Heart rate response during sleep in elderly patients after fast-track hip and knee arthroplasty

Lene Krenk, Gertrud Laura Sørensen, Henrik Kehlet, Poul Jennum

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Sleep–Wake Transition in Narcolepsy and Healthy Controls Using a Support Vector Machine

Julie Borup Jensen, Helge B. D. Sørensen, Jacob Kempfner, Gertrud Laura Sørensen et autres

Narcolepsy is characterized by abnormal sleep-wake regulation, causing sleep episodes during the day and nocturnal sleep disruptions. The transitions between sleep and wakefulness can be identified by manual scorings of a polysomnographic recording. The aim of this study was to develop an …

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Rapid Eye Movement Sleep Behavior Disorder as an Outlier Detection Problem

Jacob Kempfner, Gertrud Laura Sørensen, Marek Nikolič, Rune Asger Vestergaard Frandsen et autres

OBJECTIVE: Idiopathic rapid eye movement (REM) sleep behavior disorder is a strong early marker of Parkinson's disease and is characterized by REM sleep without atonia and/or dream enactment. Because these measures are subject to individual interpretation, there is consequently need for quantitative …

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Reduced sympathetic activity in idiopathic rapid-eye-movement sleep behavior disorder and Parkinson's disease

Gertrud Laura Sørensen, Jesper Mehlsen, Poul Jennum

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Sleep Transitions in Hypocretin-Deficient Narcolepsy

Gertrud Laura Sørensen, Stine Knudsen, Poul Jennum

STUDY OBJECTIVES: Narcolepsy is characterized by instability of sleep-wake, tonus, and rapid eye movement (REM) sleep regulation. It is associated with severe hypothalamic hypocretin deficiency, especially in patients with cataplexy (loss of tonus). As the hypocretin neurons coordinate and stabilize the brain's …

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Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy

Gertrud Laura Sørensen, Stine Knudsen, Eva Rosa Petersen, Jacob Kempfner et autres

STUDY OBJECTIVE: Several studies have suggested that hypocretin-1 may influence the cerebral control of the cardiovascular system. We analyzed whether hypocretin-1 deficiency in narcolepsy patients may result in a reduced heart rate response. DESIGN: We analyzed the heart rate response during various …

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Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease

Gertrud Laura Sørensen, Jacob Kempfner, Marielle Zoetmulder, Helge B. D. Sørensen et autres

The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep …

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Research Design of Ambulant Sleep Experiments: DCSM User Manual 2011

Jacob Kempfner, Gertrud Laura Sørensen, Helle L. Leonthin, Helge B. D. Sørensen et autres

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Automatic REM sleep detection associated with idiopathic rem sleep Behavior Disorder

Jacob Kempfner, Gertrud Laura Sørensen, Helge B. D. Sørensen, P. Jennum

UNLABELLED: Rapid eye movement sleep Behavior Disorder (RBD) is a strong early marker of later development of Parkinsonism. Currently there are no objective methods to identify and discriminate abnormal from normal motor activity during REM sleep. Therefore, a REM sleep detection without …

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Detection of arousals in Parkinson's disease patients

Gertrud Laura Sørensen, Jacob Kempfner, P. Jennum, Helge B. D. Sørensen

Arousal from sleep are short awakenings, which can be identified in the EEG as an abrupt change in frequency. Arousals can occur in all sleep stages and the number and frequency increase with age. Frequent arousals during sleep results in sleep fragmentation …

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REM Behaviour Disorder detection associated with neurodegenerative diseases

Jacob Kempfner, Gertrud Laura Sørensen, Marielle Zoetmulder, Poul Jennum et autres

UNLABELLED: Abnormal skeleton muscle activity during REM sleep is characterized as REM Behaviour Disorder (RBD), and may be an early marker for different neurodegenerative diseases. Early detection of RBD is therefore highly important, and in this ongoing study a semi-automatic method for …

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Pulse wave velocity in the carotid artery

Gertrud Laura Sørensen, Julie Brinck Jensen, Jesper Udesen, Iben Kraglund Holfort et autres

The pulse wave velocity (PWV) in the carotid artery (CA) has been estimated based on ultrasound data collected by the experimental scanner RASMUS at DTU. Data is collected from one test subject using a frame rate (FR) of 4000 Hz. The influence …

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