Martina Cappelletti

The Unexplored Role of Mitochondria-Related Oxidative Stress in Diverticular Disease

Martina Cappelletti, Lucia Pallotta, Rosa Vona, Antonella Tinari et autres

The pathophysiology of diverticular disease (DD) is not well outlined. Recent studies performed on the DD human ex vivo model have shown the presence of a predominant transmural oxidative imbalance whose origin remains unknown. Considering the central role of mitochondria in oxidative …

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From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance

Lucia Pallotta, Annalinda Pisano, Rosa Vona, Martina Cappelletti et autres

BACKGROUND: The natural history and pathophysiology of diverticular disease (DD) are still uncertain. An ex-vivo human complicated DD (cDD) model has recently shown a predominant transmural oxidative imbalance. The present study aims to evaluate whether the previously described alterations may precede the …

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OC.14.5: THE UNCHARTED MITOCHONDRIA-DRIVEN OXIDATIVE STRESS IN DIVERTICULAR DISEASE

Martina Cappelletti, Rosa Vona, Giovanni Casella, Miriam Tarallo et autres

Diverticular Disease Worsening Is Associated with Increased Oxidative Stress and Gut Permeability: New Insights by Circulating Biomarkers

Lucia Pallotta, Vittoria Cammisotto, Valentina Castellani, Margherita Spigaroli et autres

Diverticular disease (DD) management is impaired by its pathogenesis, which is still not completely defined, with an unmet clinical need for improved therapies. Ex vivo DD human models demonstrated the presence of a transmural oxidative imbalance that supports an ischemic pathogenesis. This …

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T.02.5 OXIDATIVE STRESS IN DIVERTICULAR DISEASE: MITOCHONDRIA INVOLVEMENT OF IN THE DIFFERENT CLINICAL PHENOTYPES

Martina Cappelletti, R. Vona, A. Pisano, A. Gioia et autres

OC.04.1 OXIDATIVE MUSCLE-DRIVEN ALTERATIONS: PARALLELISM BETWEEN UNCOMPLICATED AND COMPLICATED DIVERTICULAR DISEASE

Martina Cappelletti, R. Vona, A. Gioia, Lidia Castagneto‐Gissey et autres

Oxidative imbalance and muscular alterations in diverticular disease

Lucia Pallotta, Rosa Vona, M.A. Maselli, Alessia Cicenia et autres

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The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders

Rosa Vona, Lucia Pallotta, Martina Cappelletti, Carola Severi et autres

Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of many diseases. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant systems has been extensively studied in pulmonary, neurodegenerative cardiovascular disorders; however, …

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Thrombin Inhibitors in Women on Oral Contraceptives

Emma Guagnellini, Giulia Bertolini, Martina Cappelletti, Gualtiero I. Colombo

Progressive antithrombin activity and the immunological levels of antithrombin III, alpha 2-macroglobulin, and alpha 1-antitrypsin were measured in women at various intervals during treatment with oral contraceptives and in a group of untreated women. No significant changes were observed in any of …

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