Marie Kopecká

Vomiting and motion sickness in children during travel - recommendation for parents

Petra Rozsívalová, Aneta Marková, Marie Kopecká, Josef Malý

Kinetza (cestovn nevolnost) je fyziologick odpov na senzorick konflikt mezi vestibulrnm, zrakovm a proprioceptivnm systmem, postihujc nejastji dti ve vku 4-13 let. Klinick obraz zahrnuje spektrum pznak od maltnosti a zvn pes nauzeu a po zvracen. Zkladem managementu jsou nefarmakologick preventivn opaten. …

QOL-42. ANALYSIS OF LATE EVENTS AFTER RADIATION THERAPY FOR PRIMARY PEDIATRIC BRAIN TUMORS

Kateřina Trková, Aleš Vícha, Lenka Krsková, Miroslav Koblížek et autres

Abstract BACKGROUND Late events after radiation therapy for primary brain tumors consist of secondary malignant neoplasms (SMN) and tumor recurrences. The incidence and biology of late events are not very well described. Therefore, we aimed to identify late events in our institutional …

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Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?

Aleš Vícha, Pavla Jenčová, Daniela Novakova‐Kodetova, Lucie Stolova et autres

Rhabdomyosarcomas (RMS) constitute a heterogeneous spectrum of tumors with respect to clinical behavior and tumor morphology. The paternal uniparental disomy (pUPD) of 11p15.5 is a molecular change described mainly in embryonal RMS. In addition to LOH, UPD, the MLPA technique (ME030kit) also …

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Metamizol v léčbě bolesti u pediatrické populace

Petra Rozsívalová, Radek Štichhauer, Lucie Holická, Pavel Rozsival et autres

Metamizol (dipyron) je v klinicke praxi využivan již teměř 100 let jako neopioidni analgetikum se spasmolytickou ucinnosti (zejmena vyssi davky) v perioperacni lecbě bolesti a jako antipyretikum druhe volby. Vykazuje dobrý profil nežadoucich ucinků, mirne protidestickove a gastrointestinalni nežadouci ucinky. Metamizol je …

Metamizol in paediatric pain management

Petra Rozsívalová, Radek Štichhauer, Lucie Holická, Pavel Rozsival et autres

Metamizol (dipyron) je v klinické praxi využíván již téměř 100 let jako neopioidní analgetikum se spasmolytickou účinností (zejména vyšší dávky) v perioperační léčbě bolesti a jako antipyretikum druhé volby. Vykazuje dobrý profil nežádoucích účinků, mírné protidestičkové a gastrointestinální nežádoucí účinky. Metamizol je …

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Microtubules and Actin Cytoskeleton of Cryptococcus neoformans as Targets for Anticancer Agents to Potentiate a Novel Approach for New Antifungals

Marie Kopecká

BACKGROUND: We investigated the targeting of microtubules (MT) and F-actin cytoskeleton (AC) of the human pathogenic yeast Cryptococcus neoformans with agents for cancer therapy, in order to examine whether this yeast cytoskeleton could become a new antifungal target for the inhibition of …

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Effects of the F-actin inhibitor latrunculin A on the budding yeast Saccharomyces cerevisiae

Marie Kopecká, Susumu Kawamoto, Masashi Yamaguchi

Our basic cell biology research was aimed at investigating the effect on eukaryotic cells of the sudden loss of the F-actin cytoskeleton. Cells treated with latrunculin A (LA) in yeast extract peptone dextrose (YEPD) medium were examined using phase-contrast and fluorescent microscopy, …

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The Effects of the F-Actin Inhibitor Latrunculin A on the Pathogenic Yeast Cryptococcus neoformans

Marie Kopecká, Masashi Yamaguchi, Susumu Kawamoto

BACKGROUND: This basic research aimed to investigate the effects of the actin inhibitor latrunculin A (LA) on the human pathogen Cryptococcus neoformans, by freeze-substitution (FS) and electron microscopy (EM), to determine whether the actin cytoskeleton can become a new antifungal target for …

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Effects of Microtubule and Actin Inhibitors on Cryptococcus neoformans Examined by Scanning and Transmission Electron Microscopy

Marie Kopecká

BACKGROUND: Cryptococcus neoformans is one of the most important human fungal pathogens. Its cells contain rich microtubules required for nuclear division and rich F-actin cytoskeletons for cell division. Disruption of microtubules by a microtubule inhibitor should block nuclear division, and disruption of …

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Yeast and fungal cell-wall polysaccharides can self-assemblein vitrointo an ultrastructure resemblingin vivoyeast cell walls

Marie Kopecká

Polysaccharides account for more than 90% of the content of fungal cell walls, but the mechanism underlying the formation of the architecture of the cell walls, which consist of microfibrils embedded in an amorphous wall matrix, remains unknown. We used electron microscopy …

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A new F-actin structure in fungi: actin ring formation around the cell nucleus of Cryptococcus neoformans

Marie Kopecká, Susumu Kawamoto, Masashi Yamaguchi

The F-actin cytoskeleton of Cryptococcus neoformans is known to comprise actin cables, cortical patches and cytokinetic ring. Here, we describe a new F-actin structure in fungi, a perinuclear F-actin collar ring around the cell nucleus, by fluorescent microscopic imaging of rhodamine phalloidin-stained …

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Actin ring formation around the cell nucleus of long-neck yeast

Marie Kopecká, S Yoshida, Masashi Yamaguchi

The unique long-neck yeast Fellomyces fuzhouensis has F-actin cables and cortical patches. Here, we describe a new F-actin structure present in fungi, a perinuclear F-actin collar ring around the cell nucleus. This F-actin structure can be visualized by fluorescent microscopic imaging of …

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