Esmeralda Quartuccio

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero et autres

OBJECTIVE: Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long-term impact on distinct B-cell subsets is not fully understood. This …

it (code pays fourni par la source)

The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT)

Alessia Bianchi, Domenica Matranga, Francesco Patti, Laura Maniscalco et autres

OBJECTIVE: Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case-control study involving 18 Italian MS Centres investigated MS course by ethnicity and native-country economic status in foreign-born patients living …

gb, it (code pays fourni par la source)

Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial

Jacqueline Palace, Dean M. Wingerchuk, Kazuo Fujihara, Achim Berthele et autres

BACKGROUND: Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury. The PREVENT study demonstrated that the terminal complement inhibitor eculizumab reduces …

gb, us, jp, de, es, kr, tr, ru, my, tw (code pays fourni par la source)

Effect of dalfampridine on information processing speed impairment in multiple sclerosis

Laura De Giglio, Francesca De Luca, Flavia Gurreri, Ilaria Ferrante et autres

Objective To test a possible benefit of dalfampridine on information processing speed (IPS), a key function for cognitive impairment (CogIm) in multiple sclerosis (MS). Methods In this randomized, double-blind, placebo-controlled trial, we included patients with a score on the Symbol Digit Modalities …

it, lb (code pays fourni par la source)

Serum lactate as a novel potential biomarker in multiple sclerosis

Angela Maria Amorini, Viviana Nociti, Axel Petzold, Claudio Gasperini et autres

it, nl, gb (code pays fourni par la source)

Structural Brain MR Imaging Changes Associated with Obsessive-Compulsive Disorder in Patients with Multiple Sclerosis

Emanuele Tinelli, Ada Francia, Esmeralda Quartuccio, Manuela Morreale et autres

BACKGROUND AND PURPOSE: Psychiatric symptoms occur in approximately 30% of patients with MS. Such symptoms include OCD, which may interfere heavily with the patient's daily life. We hypothesized that the widespread involvement of both GM and WM, which characterizes MS, may be …

it, nz (code pays fourni par la source)