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Zana P. Desgranges, Heike Deubner, Virginia C. Broudy, Michael A. Chen
The incidence of non-Hodgkin lymphoma has increased over the past 10 years, particularly in association with human immunodeficiency virus (HIV) infection. Burkitt lymphoma is a highly aggressive non-Hodgkin lymphoma that involves the heart in up to a third of cases. This case …
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Jaya Rajaiya, Jamee C. Nixon, Neil Ayers, Zana P. Desgranges et autres
Bright/ARID3a/Dril1, a member of the ARID family of transcription factors, is expressed in a highly regulated fashion in B lymphocytes, where it enhances immunoglobulin transcription three- to sixfold. Recent publications from our lab indicated that functional, but not kinase-inactive, Bruton's tyrosine kinase …
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Zana P. Desgranges, Ananda L. Roy
Reproduction, or the faithful passage of genetic information from one cell to its progeny, is central to life. To achieve reproduction faithfully cells have developed the cell cycle during which error-free replication of DNA, followed by division of the nucleus and partitioning …
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Zana P. Desgranges, Maria B. Lazebnik, Todd D. Ashworth, Caleb Lee et autres
The multifunctional transcription factor TFII-I is tyrosine phosphorylated in response to extracellular growth signals and transcriptionally activates growth-promoting genes. However, whether activation of TFII-I also directly affects the cell cycle profile is unknown. Here we show that under normal growth conditions, TFII-I …
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Venugopalan Cheriyath, Zana P. Desgranges, Ananda L. Roy
TFII-I is a multifunctional transcription factor that is also involved in signal transduction. Here we show that TFII-I undergoes a c-Src-dependent tyrosine phosphorylation on tyrosine residues 248 and 611 and translocates to the nucleus in response to growth factor signaling. Tyrosine-phosphorylated nuclear …
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