Isabel Carreras

Protection of multiple aspects of Alzheimer’s disease pathology using dietary supplementation with taurine

Christina M. Tognoni, Rajshree Ghosh Biswas, Zeynep Melis Suar, Isabel Carreras et autres

As Alzheimer’s disease (AD) continues to rise amongst the aging population, preventative measures such as dietary or lifestyle changes represent an attractive option to mitigate the burden. Taurine, known for its antioxidant and anti-inflammatory properties, may also play a neuroprotective role. This …

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Protection of multiple aspects of Alzheimer’s disease pathology using dietary supplementation with taurine

Christina M. Tognoni, Rajshree Ghosh Biswas, Zeynep Melis Suar, Isabel Carreras et autres

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P1.07.04 MRD Combined With Radiological Tumor Volume as Tool to Identify Resected NSCLC Patients at High Risk of Recurrence

Michela Verzè, R. Minari, Paola Bordi, Giovanni Bocchialini et autres

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Assessing the protective roles of taurine in Alzheimer's disease mouse models

Zeynep Melis Suar, Rajshree Ghosh Biswas, Christina M. Tognoni, Isabel Carreras et autres

Motivation: The current strategies of targeting patients with Alzheimer's Disease (AD) suggest that preventative therapies might be more efficient than repairing extensive pathology in progressed AD. Goal(s): We aim to see if taurine can prevent or slow down the progression of AD …

MRS Metabolic Differentiation of Alzheimer’s Disease in Mice Across Three Brain Regions to Explore Changes in Response to Anesthesia in Surgery

Rajshree Ghosh Biswas, Zeynep Suar, Christina M. Tognoni, Isabel Carreras et autres

Motivation: Use MRS-based metabolomics to differentiate brain regions between wildtype and 'early-stage' AD (3-4mo) mice, creating a baseline molecular profile to assess changes in response to AD-promoting stimuli. Goal(s): Identify metabolomic differences in: frontal cortex, dorsal hippocampus (DHP) and ventral hippocampus (VHP). …

225P: Circulating tumor DNA as a prognostic biomarker in unresectable locally advanced NSCLC

N. Navarro-Gorro, L. Masfarre Pinto, P.F. Simoes da Rocha, Antı́gona Martı́nez et autres

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Overactivation of Akt/Mtor Signaling and Decreased Expression of P27 Kip1 Associates with Motor Neuron Neurodegeneration in the Spinal Cord of Als Patients

Younghun Jung, Christina M. Tognoni, Omer Aksut, Jacob R. Lepre et autres

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Amyloid-β neuropathology induces bone loss in male mice by suppressing bone formation and enhancing bone resorption

Younghun Jung, Birol Ay, Sajin Marcus Cyr, Christina M. Tognoni et autres

Alzheimer's disease (AD) and osteoporosis often coexist in the elderly. Although observational studies suggest an association between these two diseases, the pathophysiologic link between AD and skeletal health has been poorly defined. We examined the skeletal phenotype of 5xFAD mice, an AD …

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Microglial cell response to experimental periodontal disease

Rawan Almarhoumi, Carla Álvarez, Theodore Harris, Christina M. Tognoni et autres

Abstract Objectives Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in forming barriers around extracellular neuritic plaques and the phagocytosis of β-amyloid peptide (Aβ). In this …

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Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NFκB

Isabel Carreras, Younghun Jung, Jonathan Lopez-Benitez, Christina M. Tognoni et autres

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Sphingosine 1‐phosphate receptor signaling is dysregulated in a mouse model of Alzheimer's disease

Younghun Jung, Jonathan Lopez-Benitez, Christina M. Tognoni, Isabel Carreras et autres

Abstract Background Sphingosine 1‐phosphate (S1P) through the activation of five G‐protein‐coupled S1P receptors 1‐5 (S1PR1‐5) plays crucial roles in cellular events. Aberrant sphingolipid metabolism has been identified in the brains of Alzheimer’s disease (AD) patients which implies the significance of S1P/S1PR signaling …

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Dysregulation of sphingosine-1-phosphate (S1P) and S1P receptor 1 signaling in the 5xFAD mouse model of Alzheimer’s disease

Younghun Jung, Jonathan Lopez-Benitez, Christina M. Tognoni, Isabel Carreras et autres

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