Allyson Alexander

Effect of time to palliative epilepsy surgery on outcomes

Robert M. Crutcher, David Horvat, Avery R. Caraway, Kristen H. Arredondo et autres

OBJECTIVE: Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy duration and seizure …

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Disparities across the pediatric epilepsy surgery journey: Referral, recommendation, and completion from a national consortium

Madison M. Berl, Janelle L. Wagner, Avery Robert Caraway, Hayley Loblein et autres

OBJECTIVE: Despite being safe and effective, surgery for pediatric epilepsy is underutilized. Social determinants of health (SDoH) are important to consider when examining this treatment gap. This study examined the potential systemic inequities at three different stages in the journey toward epilepsy …

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4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2–5 (Kv7.2-Kv7.5) channels

J. Keenan Kushner, Paige Hoffman, Christine R. Brzezinski, Brent R. O'Neill et autres

Epilepsy is one of the most common neurological disorders worldwide. Despite the availability of many anti-seizure medicines (ASMs), about 30 % of patients with epilepsy develop drug-resistant epilepsy. Unfortunately, the mechanisms of ictogenesis in patients with drug-resistant epilepsy remain to be elucidated. …

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The Association Between Chiari Malformation I and Syndromic and Non-syndromic Craniosynostosis: A Systematic Review

Skyler K. Palmer, Jasmine Chaij, Diane Saab, Anna Lee et autres

Introduction: Chiari malformation I (CM1) often results from craniocerebral disproportion such as that caused by craniosynostosis (CS). The association between CM1 and CS has been described in several retrospective studies, but a comprehensive meta-analysis of the cumulative data has not been reported. …

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Factors Associated With More Medication Trials Before Surgical Evaluation and Postsurgical Outcomes in Pediatric Drug-Resistant Epilepsy

Debopam Samanta, Avery Robert Caraway, Gregory W. Albert, Edward J. Novotny et autres

BACKGROUND AND OBJECTIVES: Despite strong evidence supporting timely surgical evaluation, many children with drug-resistant epilepsy undergo multiple antiseizure medication (ASM) trials before surgery. Because guidelines recommend evaluation after failure of 2 appropriate ASMs, evaluation after failure of >2 ASMs serves as a …

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Outcomes of Early-Life Focal Cortical Dysplasia–Related Epilepsy

Nathan T. Cohen, Dewi Depositario‐Cabacar, Chima Oluigbo, Adam P. Ostendorf et autres

Background and Objectives: Focal cortical dysplasia (FCD) is the most common cause of surgically treatable drug-resistant epilepsy (DRE) in children. Surgical outcomes are poorly defined in early-onset FCD-DRE. The purpose of this study was to evaluate clinical and presurgical characteristics relating to …

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Secondary Cranioplasty After Fronto-Orbital Advancement: Analysis of a National Database

Anna D. Lee, Skyler K. Palmer, Diego A. Gomez, Elliot Le et autres

INTRODUCTION: Fronto-orbital advancement (FOA) is the standard treatment for craniosynostosis patients with fronto-orbital dysmorphology. Few studies examine the incidence of secondary cranioplasty operations after FOA. This retrospective analysis utilizes multicenter billing data to identify risk factors and the incidence of secondary reconstructive …

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Factors Influencing the Duration From the Initiation of Surgical Evaluation to Final Intervention in Pediatric Epilepsy Surgery

Ruba Al‐Ramadhani, Ann Hyslop, Avery Robert Caraway, Edward J. Novotny et autres

Rationale: Longer duration of epilepsy before surgery is a predictor of poor outcome. While referral delays of surgical candidates are well documented, factors causing delay during the presurgical evaluation remain unclear and may vary depending on institutional characteristics. By benchmarking the duration …

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SP26. Chiari 1 Malformation in Non-Syndromic and Syndromic Craniosynostoses: A Meta-Analysis

Jasmine Chaij, Diane Saab, Anna Lee, Allyson Alexander et autres

PURPOSE: Chiari I malformation (CM) is typically the result of either caudal traction or craniocerebral disproportion. Craniosynostosis (CS), the premature fusion of cranial sutures, can result in craniocerebral disproportion and thus has been associated with CM. Although there are studies with small …

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Characterizing the Diversity of Layer 2/3 Human Neocortical Neurons in Pediatric Epilepsy

J. Keenan Kushner, Paige Hoffman, Christine Brzezinski, Matthew N. Svalina et autres

Childhood epilepsy is a common and devastating condition, for which many children still do not have adequate treatment. Some children with drug-resistant epilepsy require surgical excision of epileptogenic brain tissue for seizure control, affording the opportunity to study this tissue ex vivo …

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1159 Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MRgLITT) Compared With Resective Surgery in Pediatric Patients With Refractory Epilepsy: Indications, Outcomes, and Considerations

William B. Harris, Jia‐Shu Chen, Allyson Alexander

INTRODUCTION: Epilepsy affects up to 0.5% of children, with one-third considered for surgery due to medical refractoriness. Studies show surgery offers better seizure freedom for drug-resistant epilepsy than medical therapy. However, it is underutilized due to potential complications and postoperative deficits, which …

Investigation of Cranial Bone Changes Indicative of Increased Intracranial Pressure in Diverse Phenotypes of Craniosynostosis

Jasmine Chaij, Jiawei Liu, Brooke French, David M. Mirsky et autres

Background: Despite the clinical importance of identifying increased intracranial pressure (IIP) in children with craniosynostosis (CS), its presence is often uncertain due to limited utilization of invasive measurement methods, inconclusive clinical evaluations, and its variability depending on the CS phenotype. Hence, prevalence …

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