David R. Bryant

New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma

Roberto ROMERO, Gaurav Bhatti, Tinnakorn CHAIWORAPONGSA, Nardhy GOMEZ-LOPEZ et autres

us, th, kr (code pays fourni par la source)

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics

Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel et autres

[This corrects the article DOI: 10.1016/j.isci.2025.113181.].

Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia

Ina Jungersen Andresen, Roberto Romero, Ane C. Westerberg, Nándor Gábor Than et autres

BACKGROUND: Preeclampsia is classified as either a more severe early onset or a more prevalent late-onset form. Lower PlGF (placental growth factor) and increased sFlt-1 (fms-like tyrosine kinase-1) in maternal circulation are promising biomarkers, yet they lack specificity for preeclampsia. METHODS: We …

no, us, hu, dk, nz, in (code pays fourni par la source)

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics

Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel et autres

Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models. Herein, we curated 1,842 public placental methylomes and organized a DREAM challenge to develop models of gestational age. Participants were …

us, tw, de, gb (code pays fourni par la source)

Proteomic Profiles of Maternal Plasma Extracellular Vesicles for Prediction of Preeclampsia

Nándor Gábor Than, Roberto Romero, Wendy Fitzgerald, Dereje W. Gudicha et autres

PROBLEM: Preeclampsia is a heterogeneous syndrome of diverse etiologies and molecular pathways leading to distinct clinical subtypes. Herein, we aimed to characterize the extracellular vesicle (EV)-associated and soluble fractions of the maternal plasma proteome in patients with preeclampsia and to assess their …

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Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing

Valeria Garcia‐Flores, Roberto Romero, Adi L. Tarca, Azam Peyvandipour et autres

Labor is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. However, the cellular contributions and communications that facilitate maternal-fetal cross-talk in labor have not been fully elucidated. Here, single-cell RNA sequencing (scRNA-seq) was applied to decipher maternal-fetal …

us, cl, th (code pays fourni par la source)

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors

Tinnakorn Chaiworapongsa, Roberto Romero, Nardhy Gomez‐Lopez, Manaphat Suksai et autres

us, th, co, kr (code pays fourni par la source)

Immunosequencing and Profiling of T Cells at the Maternal–Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis

Derek Miller, Roberto Romero, Luke Myers, Yi Xu et autres

T cells are implicated in the pathophysiology of preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Specifically, maternal decidual T cells infiltrate the chorioamniotic membranes in chronic chorioamnionitis (CCA), a placental lesion considered to reflect maternal anti-fetal …

us, cl (code pays fourni par la source)

The Impact of Peripartum Floor Lockdowns on Newborn Safety

Barbara Neshek, David R. Bryant, Justin Hruska, Deepak K. Gupta

Abstract Background For the safety of newborns, infrastructural lockdown of peripartum floors may be imperative. Materials and Methods Cumulative data with no identifiers at all was collected from Midas Incident Reporting System reports and Security Logs reports for comparing incidence of newborn …

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SARS-CoV-2 Virus Not Detected in Meconium Samples of Neonates Born to COVID-19 Positive Parturients

Laura Mroue, Jorge Lua, Gil Mor, David R. Bryant et autres

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Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia – implications for clinical care

Roberto Romero, Percy Pacora, Juan Pedro Kusanovic, Eunjung Jung et autres

OBJECTIVES: Clinical chorioamnionitis at term is considered the most common infection-related diagnosis in labor and delivery units worldwide. The syndrome affects 5-12% of all term pregnancies and is a leading cause of maternal morbidity and mortality as well as neonatal death and …

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A Non-Lethal Osteogenesis Imperfecta Type II Mutation

Ali Alhousseini, Maheshwar Mahaseth, Salam Zeineddine, Sunil Jaiman et autres

BACKGROUND: We discuss the ethical decision points in a case report that describes a novel COL1A1 mutation associated to Osteogenesis Imperfecta type II, but with a non-lethal outcome. CASE: A 33-year-old female underwent a 21-week ultrasound that revealed short bowed femurs and …

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