Michael P. DeLorme

Review of Health and Safety Data on Leading SF6-alternative Gas Mixtures

John G. Owens, Agnes Zhang, J.J. Bonk, Michael P. DeLorme

One of the continuing environmental challenges for the electric power industry results from the use of sulfur hexafluoride (SF6) as a dielectric medium in gas-insulated equipment due to its identification as a potent greenhouse gas. The electric power industry has long searched …

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Evaluation of Sustainable SF 6 Alternative Gas Mixtures Used in Electric Power Equipment

R. V. San, Ang Xiao, J.J. Bonk, Michael P. DeLorme et autres

Sulfur hexafluoride, SF6, has been the preferred dielectric medium in electrical power applications for decades. However, due to its extremely long atmospheric lifetime and very high global warming potential the industry is designing SF6-free technologies for many applications, including switchgear, circuit breakers …

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Recent Development of Two Alternative Gases to SF6 for High Voltage Electrical Power Applications

John G. Owens, Ang Xiao, J.J. Bonk, Michael P. DeLorme et autres

For many years, SF6 has been the preferred dielectric medium in electrical power applications, particularly in high voltage gas-insulated equipment. However, with the recognition that SF6 has an extremely long atmospheric lifetime and very high global warming potential, governments have pursued emission …

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Recent Development of Alternative Gases to SF6for High Voltage Electrical Power Applications

Ang Xiao, Agnes Zhang, J.J. Bonk, John G. Owens et autres

For many years, SF6has been the preferred dielectric medium in electrical power applications, particularly in high voltage gas-insulated equipment. However, with the recognition that SF6has an extremely long atmospheric lifetime and very high global warming potential, governments have pursued emission reductions from …

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Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Amy J. Clippinger, David Allen, Holger Peter Behrsing, Kelly BéruBé et autres

New approaches are needed to assess the effects of inhaled substances on human health. These approaches will be based on mechanisms of toxicity, an understanding of dosimetry, and the use of in silico modeling and in vitro test methods. In order to …

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An exposure assessment approach for potential thermal degradation compounds in 2‐phase immersion cooling operations

Phillip E. Tuma, Jay F. Schulz, J.J. Bonk, Robert J. Le Roy et autres

Passive 2‐phase immersion cooling (P2PIC) is a technique for cooling computers with the potential to reduce capital and operating costs within datacenters. Computers cooled by P2PIC are submerged in a fluorochemical liquid that boils (hence 2‐phase) from the heat generating components. Although …

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Subchronic Inhalation Toxicity Study in Rats With Carbon Nanofibers: Need for Establishing a Weight‐of‐Evidence Approach for Setting no Observed Adverse Effect Levels (NOAEL s )

David B. Warheit, Ken L. Reed, Michael P. DeLorme

This chapter assess the toxicity of aerosolized CNFs in male and female rats over a 13- week period, using the OECD 413 testing guidelines. In addition, to supplement the standardized toxicological endpoints, investigations using bronchoalveolar lavage parameters and cell proliferation methods were …

Jet Fuel Kerosene is not Immunosuppressive in Mice or Rats Following Inhalation for 28 Days

Kimber L. White, Michael P. DeLorme, Patrick W. Beatty, Matthew J. Smith et autres

Previous reports indicated that inhalation of JP-8 aviation turbine fuel is immunosuppressive. However, in some of those studies, the exposure concentrations were underestimated, and percent of test article as vapor or aerosol was not determined. Furthermore, it is unknown whether the observed …

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Subchronic inhalation of carbon nanofibers: No apparent cross-talk between local pulmonary and cardiovascular/systemic responses

David B. Warheit, Kenneth L. Reed, Michael P. DeLorme

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Embracing a Weight-of-Evidence Approach for Establishing NOAELs for Nanoparticle Inhalation Toxicity Studies

David B. Warheit, Kenneth L. Reed, Michael P. DeLorme

The goal of this article is to evaluate a recently published subchronic inhalation study with carbon nanofibers in rats and discuss the importance of a weight-of-evidence (WOE) framework for determining no adverse effect levels (NOAELs). In this Organization for Economic Cooperation and …

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CNT biopersistence and the fibre paradigm

David B. Warheit, Michael P. DeLorme

Ninety-Day Inhalation Toxicity Study With A Vapor Grown Carbon Nanofiber in Rats

Michael P. DeLorme, Yukihiro Muro, Toshihiro Arai, Deborah A. Banas et autres

A subchronic inhalation toxicity study of inhaled vapor grown carbon nanofibers (CNF) (VGCF-H) was conducted in male and female Sprague Dawley rats. The CNF test sample was composed of > 99.5% carbon with virtually no catalyst metals; Brunauer, Emmett, and Teller (BET) …

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