Emily Tenshaw

Comparative connectomics of Drosophila descending and ascending neurons

Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila, Billy J Morris et autres

Abstract In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains most of the final motor outputs necessary for behaviour, and the brain. In insects, the neck connective is both a physical and an information …

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Discovery of neuronal cell types by pairing whole cell reconstructions with RNA expression profiles

Tiago Ferreira, Mark Eddison, Monique Copeland, Monet Weldon et autres

Abstract Effective classification of neuronal cell types requires both molecular and morphological descriptors to be collected in situ at single-cell resolution. However, current spatial transcriptomics techniques are not compatible with imaging workflows that successfully reconstruct the morphology of complete axonal projections. Here, …

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Comparative connectomics of the descending and ascending neurons of the Drosophila nervous system: stereotypy and sexual dimorphism

Tomke Stürner, P. D. Brooks, Laia Serratosa Capdevila, Billy J Morris et autres

Abstract In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains most of the final motor outputs necessary for behaviour, and the brain. In insects, the neck connective is both a physical and information bottleneck …

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Reconstructing Complete Neurons in Whole Brains Using HortaCloud v1

Emily Tenshaw, Alyssa K. Stark, Monet Weldon, Cameron Arshadi

Complete and accurate reconstruction of axonal arbors is a challenging task because axons are very thin, with diameters of less than 100 nanometers, and traverse large distances (up to 60 centimeters in the mouse brain).This protocol documents the workflow used by the …

Publisher Correction: Synaptic gradients transform object location to action

Mark Dombrovski, Martin Y. Peek, Jin-Yong Park, Andrea Vaccari et autres

In the version of this article originally published, the x -axis labels for Figure 3e,f,i and j incorrectly read “Disc size (°)” and have been corrected to read “Azimuth (°)” in the HTML and PDF versions of the article.

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Synaptic gradients transform object location to action: data and outputs

Mark Dombrovski, Martin Y. Peek, Jin-Yong Park, Andrea Vaccari et autres

Data an outputs associated with the following article: Dombrovski, M., Peek, M.Y., Park, JY. et al. Synaptic gradients transform object location to action. Nature (2023). https://doi.org/10.1038/s41586-022-05562-8 and the following software: https://github.com/avaccari/DrosophilaVPNWiring

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Synaptic gradients transform object location to action: data and outputs

Mark Dombrovski, Martin Y. Peek, Jin-Yong Park, Andrea Vaccari et autres

Data an outputs associated with the following article: Dombrovski, M., Peek, M.Y., Park, JY. et al. Synaptic gradients transform object location to action. Nature (2023). https://doi.org/10.1038/s41586-022-05562-8 and the following software: https://github.com/avaccari/DrosophilaVPNWiring

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Synaptic gradients transform object location to action

Mark Dombrovski, Martin Y. Peek, Jin-Yong Park, Andrea Vaccari et autres

Abstract To survive, animals must convert sensory information into appropriate behaviours1,2. Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses3–5. How circuitry converts object location in retinal coordinates to movement direction in body coordinates remains largely unknown. …

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A connectome and analysis of the adult Drosophila central brain

Louis K. Scheffer, C. Shan Xu, Michał Januszewski, Zhiyuan Lu et autres

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster . Improved methods include new procedures to prepare, image, align, segment, …

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Author response: A connectome and analysis of the adult Drosophila central brain

Louis K. Scheffer, C. Shan Xu, Michał Januszewski, Zhiyuan Lu et autres

Animal brains of all sizes, from the smallest to the largest, work in broadly similar ways. Studying the brain of any one animal in depth can thus reveal the general principles behind the workings of all brains. The fruit fly Drosophila is …

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A Connectome and Analysis of the Adult Drosophila Central Brain

Louis K. Scheffer, C. Shan Xu, Michał Januszewski, Zhiyuan Lu et autres

Abstract The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, …

us, ca, jp, de (code pays fourni par la source)

A Connectome of the Adult Drosophila Central Brain

C. Shan Xu, Michał Januszewski, Zhiyuan Lu, Shin-ya Takemura et autres

Abstract The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize …

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