Ming‐Chang Chiang

Subclinical cardiomyopathy in premanifest carriers of late-onset hereditary transthyretin amyloidosis with polyneuropathy

Te-Wei Wang, Mao‐Yuan Su, Mei‐Fang Cheng, Hsueh‐Wen Hsueh et autres

Background Cardiac involvement is a common presentation of late-onset hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN). This study explored phenotypes of cardiac amyloidosis and their clinical and neurological correlates in the premanifest stage. Methods Premanifest carriers with the transthyretin p.A117S variant were enrolled. …

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Cortical disinhibition in peripheral neuropathy unveiled by exploratory analysis of spectral alterations in contact heat–evoked potential

Chung-Wei Lee, Chien‐Ho Lin, Hsueh‐Wen Hsueh, Te-Wei Wang et autres

ABSTRACT: Neuropathic pain affects 20% to 60% of patients with peripheral neuropathy, generally considered a consequence of nociceptor hypersensitivity. Nevertheless, persistent peripheral nociceptive input may induce central sensitization, a maladaptive neuroplasticity that amplifies neuropathic pain. Contact heat-evoked potential (CHEP) measurement noninvasively assesses …

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Glutathione-conjugated gold nanoparticles mitigate amyloid-beta-induced neuroinflammation and tauopathy through inhibition of NF-κB, the NLRP3 inflammasome axis in 3D human neural stem cell models

Yuping Yang, Christopher J.B. Nicol, Chiahui Yen, Ming‐Chang Chiang

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Magnetic Field-Guided Magnetic Nanoparticles as Neurotherapeutics for Neurological Disorders and Glioblastoma

Ming‐Chang Chiang, Yu-Ping Yang, Christopher J.B. Nicol

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke, are among the most devastating neurological disorders worldwide. Glioblastoma (GBM) is a rapidly growing cancer that originates in astrocytes in the brain. It invades and damages the nervous system. Current treatment …

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Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation

Chiahui Yen, Ming‐Chang Chiang

Chronic pain is a pervasive and debilitating condition that affects millions of individuals worldwide. Unlike acute pain, which serves a protective physiological role, chronic pain persists beyond routine tissue healing and often arises without a discernible peripheral cause. Accumulating evidence indicates that …

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A Review of the Neuroprotective Properties of Exosomes Derived from Stem Cells and Exosome-Coated Nanoparticles for Treating Neurodegenerative Diseases and Stroke

Yuping Yang, Christopher J.B. Nicol, Ming‐Chang Chiang

Neurological diseases, including neurodegenerative disorders and stroke, represent significant medical challenges due to their complexity and the limitations of current treatment approaches. This review explores the potential of stem cell (SC)-derived exosomes (Exos) as a transformative therapeutic strategy for these diseases. Exos, …

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Cortical reorganization in neuropathic pain due to peripheral nerve degeneration: altered cortical surface morphometry and hierarchical topography

Chien‐Ho Lin, Hsueh‐Wen Hsueh, Ming‐Chang Chiang, Sung‐Tsang Hsieh et autres

ABSTRACT: Degeneration of peripheral nerves causes neuropathic pain. Previous studies have documented structural and functional brain alterations in peripheral neuropathy, which may be attributed to maladaptive plasticity following chronic neuropathic pain. Nevertheless, the effects of peripheral neuropathic pain on the macroscale organization …

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The α-MG exhibits neuroprotective potential by reducing amyloid beta peptide-induced inflammation, oxidative stress, and tau aggregation in human neural stem cells

Ming‐Chang Chiang, Christopher J.B. Nicol, Yuping Yang, Chiahui Yen

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Protective effects of resveratrol against PM2.5-induced damage in hNSCs and its mitigation of PM2.5-induced mitochondrial dysfunction in a 3D scaffold system

Ming‐Chang Chiang, Christopher J.B. Nicol, Yuping Yang, Chiahui Yen

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Implications of perivascular spaces in amyotrophic lateral sclerosis: clinical significance and structural correlation

Sung‐Ju Hsueh, Hsueh‐Wen Hsueh, Ya‐Fang Chen, Ta‐Fu Chen et autres

Perivascular space (PVS) dysfunction may potentially contribute to the development and progression of amyotrophic lateral sclerosis (ALS). This study investigated the clinical relevance of PVS dysfunction in ALS. Two PVS parameters were quantified in patients with ALS: (i) the enlarged perivascular space …

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Multiscale Image Registration for Stroke Lesion Analysis in Rat Brain MR and Atlas Images

Herng-Hua Chang, Shin‐Joe Yeh, Ming‐Chang Chiang, Sung‐Tsang Hsieh

With the rapid development of medical imaging technology, modern imaging techniques reveal distinct image information. Image registration can integrate multimodal images to present the corresponding physiological tissues, which plays an indispensable role in clinical treatment and analysis. This paper focuses on the …

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Diflunisal versus tafamidis on neuropathy and cardiomyopathy in hereditary transthyretin amyloidosis

Chi‐Chao Chao, Shiou‐Ru Tzeng, Ming‐Chang Chiang, Hsueh‐Wen Hsueh et autres

Abstract Objectives Hereditary transthyretin (TTR) amyloidosis (ATTRv) is frequently complicated by polyneuropathy (ATTRv‐PN) and cardiomyopathy (ATTRv‐CM). The long‐term efficacy of diflunisal on both polyneuropathy and cardiomyopathy in ATTRv patients, especially those with non‐V30M genotypes, has not been fully investigated and compared with …

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