Accès ouvert
2026
article
OpenAlex
Cristina García‐Caballero, Cristina Morilla‐Lomeña, Marta Vicario-de-la-Torre, Vanessa Andrés‐Guerrero et autres
In this study, the suitability of organotypic cultures of neonatal rat retina as a controlled ex vivo platform for the evaluation of intraocular microparticulate drug delivery systems is assessed, while also exploring their ability to identify formulation-dependent differences. Poly(lactic-co-glycolic acid) (PLGA) microspheres …
es, de
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2025
book-chapter
OpenAlex
Ana Judith Perisé-Barrios, Daniel Sepúlveda‐Crespo, Dzmitry Shcharbin, Beatriz Rasines et autres
Dendrimers are polymeric macromolecules constituted of a repetitive sequence of monomers growing step-by-step from a multifunctional core in a radial iterative fashion, not by polymeric reactions. Their syntheses offer the opportunity to generate monodisperse, structure-controlled architectures resulting in useful specific biomedical applications. …
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Accès ouvert
2025
article
OpenAlex
Miriam Ana González-Cela-Casamayor, María Jesús Rodrigo, Marco Brugnera, Inés Munuera et autres
Glaucoma is a multifactorial neurodegenerative disease that affects the retina and optic nerve. The aim of this work was to reach different therapeutics targets by co-encapsulating three neuroprotective substances with hypotensive (latanoprost), antioxidant (melatonin) and anti-inflammatory (ketorolac) activity in biodegradable poly (lactic-co-glycolic …
es
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Accès ouvert
2025
article
OpenAlex
Marco Brugnera, Marta Vicario‐de‐la‐Torre, Miriam Ana González-Cela-Casamayor, Felipe M. González‐Fernández et autres
Frequent topical administration of hypotensive eye drops in glaucoma patients may lead to the development of dry eye disease (DED) symptoms, because of tear film destabilization and the adverse effects associated with antiglaucoma formulations. To address all this, in the current study …
es, it
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Accès ouvert
2024
article
OpenAlex
Alba Aragón-Navas, María Jesús Rodrigo, Inés Munuera, David García-Herranz et autres
This work focused on the co-encapsulation and simultaneous co-delivery of three different neuroprotective drugs in PLGA (poly(lactic-co-glycolic acid) microspheres for the treatment of glaucoma. For formulation optimization, dexamethasone (anti-inflammatory) and ursodeoxycholic acid (anti-apoptotic) were co-loaded by the solid-in-oil-in-water emulsion solvent extraction-evaporation technique …
es
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Accès ouvert
2024
preprint
OpenAlex
Alba Aragón-Navas, María Jesús Rodrigo, Inés Munuera, David García-Herranz et autres
Abstract This work focused on the co-encapsulation and simultaneous co-delivery of three different neuroprotective drugs in PLGA (poly(lactic-co-glycolic acid) microspheres for the treatment of glaucoma. For formulation optimization, dexamethasone (anti-inflammatory) and ursodeoxycholic acid (anti-apoptotic) were co-loaded by the solid-in-oil-in-water emulsion solvent extraction-evaporation …
es
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Accès ouvert
2024
article
OpenAlex
Marco Brugnera, Marta Vicario‐de‐la‐Torre, Miriam Ana González-Cela Casamayor, José Javier López-Cano et autres
Abstract The first line of glaucoma treatment focuses on reducing intraocular pressure (IOP) through the prescription of topical prostaglandin analogues, such as latanoprost (LAT). Topical ophthalmic medicines have low bioavailability due to their rapid elimination from the ocular surface. Nanotechnology offers innovative …
es
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Accès ouvert
2024
article
OpenAlex
Javier Rodríguez Villanueva, Pedro de la Villa, Rocío Herrero‐Vanrell, Irene Bravo‐Osuna et autres
Excitotoxicity has been linked to the pathogenesis of several serious degenerative ocular diseases. Long-term overactivation of the NMDA receptor by glutamate in retinal ganglion cells (RGCs) results in degeneration, apoptosis and loss of function leading to blindness. NMDA receptor antagonists have been …
es
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Accès ouvert
2024
article
OpenAlex
María Jesús Rodrigo, Manuel Subías, Alberto Montolío, Teresa Martínez et autres
Glaucoma is a multifactorial pathology involving the immune system. The subclinical immune response plays a homeostatic role in healthy situations, but in pathological situations, it produces imbalances. Optical coherence tomography detects immune cells in the vitreous as hyperreflective opacities and these are …
es
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2024
article
OpenAlex
Cristina Morilla‐Lomeña, Blanca Reguera‐Insausti, Vanessa Andrés‐Guerrero, Marta Vicario‐de‐la‐Torre et autres
Purpose: Anti‐inflammatory and antioxidant evaluation of idebenone (IDB) in ARPE‐19 cell line and subsequent encapsulation in PLGA (polylactic‐co‐glycolic‐acid)/vitamin E microspheres (MS), together with neurotrophic factors, to confer additional neuroprotective activity and technological advantages. Methods: ARPE‐19, a human RPE cell line, were incubated …
es
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Accès ouvert
2023
article
OpenAlex
Inés Munuera, Alba Aragón-Navas, Pilar Villacampa, Miriam A. Gonzalez-Cela et autres
To evaluate a new animal model of chronic glaucoma induced using a single injection of fibronectin-loaded biodegradable PLGA microspheres (Ms) to test prolonged therapies. 30 rats received a single injection of fibronectin-PLGA-Ms suspension (MsF) in the right eye, 10 received non-loaded PLGA-Ms …
es
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Accès ouvert
2023
article
OpenAlex
Alba Aragón-Navas, José Javier López-Cano, Melissa Johnson, A Sigen et autres
This paper aims to develop smart hydrogels based on functionalized hyaluronic acid (HA) and PLGA-PEG-PLGA (PLGA,poly-(DL-lactic-co-glycolic acid); PEG,polyethylene glycol) for use as intraocular drug-delivery platforms. Anti-inflammatory agent dexamethasone-phosphate (0.2 %w/v) was the drug selected to load on the hydrogels. Initially, different ratios …
es, ie
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