Bruna Araújo dos Santos

Cyclic GMP–AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress

Mrigya Babuta, Aditi Ashish Datta, Marcelle de Carvalho Ribeiro, Bruna Araújo dos Santos et autres

BACKGROUND: Cyclic GMP-AMP synthase (cGAS) catalyzes the production of cGAMP, which activates the STING-IRF3 signaling pathway. Previous investigations indicated a role for STING-IRF3 in early alcohol-associated liver disease (ALD). In this study, we examined the role of cGAS in liver damage and …

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Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes

Anaysa Paola Bolin, Flaviane de Fátima Silva, Rafael Barrera Salgueiro, Bruna Araújo dos Santos et autres

Abstract Chronic and excessive glucocorticoid (GC) exposure can cause Cushing's syndrome, resulting in fat accumulation in selected body areas. Particularly in the brown adipose tissue (BAT), GC acts negatively, resulting in whitening of the tissue. We hypothesized that dysregulation of microRNAs by …

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Deleção da oligopeptidase thop1 regride quadro de esteatohepatite severa em camundongos: possível interação entre peptídeos e microRNAs.

Bruna Araújo dos Santos

A doença hepática gordurosa não alcoólica (DHGNA) compreende um espectro de doenças que vai desde a presença de esteatose hepática (acúmulo de gordura no parênquima hepático sem inflamação) na ausência do consumo excessivo de álcool até a esteatohepatite, caracterizada pela esteatose junto …

MicroRNA miR-222 mediates pioglitazone beneficial effects on skeletal muscle of diet-induced obese mice

Mariana de Mendonça, Érica de Sousa, Ailma Oliveira da Paixão, Bruna Araújo dos Santos et autres

Pioglitazone belongs to the class of drugs thiazolidinediones (TZDs) and is an oral hypoglycemic drug, used in the treatment of type 2 diabetes, which improves insulin sensitivity in target tissues. Adipose tissue is the main target of pioglitazone, a PPARg and PPARa …

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Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet

Mariana de Mendonça, Bruna Araújo dos Santos, Érica de Sousa, Alice Cristina Rodrigues

Pioglitazone has been used for the treatment of nonalcoholic fatty liver disease (NAFLD) related to diabetes. The role of adiponectin in pioglitazone-induced improvements in NAFLD was studied by using wild-type (adipoWT) and adiponectin knockout (adipoKO) mice. High-fat diet fed mice were insulin …

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