Michèle C. Darmon

CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Melody Atkins, Maud Wurmser, Michèle C. Darmon, F. Hoffmann-La Roche et autres

Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill characterised. Here, we show that altering …

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CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Melody Atkins, Michèle C. Darmon, F. Hoffmann-La Roche, Xavier Nicol et autres

Summary Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill characterised. Here, we show that …

fr (code pays fourni par la source)

Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the Intensive Care Unit: The Outcomerea Database, 1997-2018

Louis-Marie Galerneau, Sabine Bailly, Nicolas Terzi, S. Ruckly et autres

fr (code pays fourni par la source)

ICU Strain Is Associated with ICU Outcome in COVID-19 Patients - a Multicenter Retrospective Observational Study Comparing the First and Second Wave of the Pandemic

Alexandre Demoule, Muriel sarah Fartoukh, Guillaume Louis, Élie Azoulay et autres

fr (code pays fourni par la source)

The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex

Florian Rebeillard, Stéphanie De Gois, Nicolas Pietrancosta, Thi Hue et autres

GPR88 is an orphan G-protein-coupled receptor (GPCR) highly expressed in striatal medium spiny neurons (MSN), also found in cortical neurons at low level. In MSN, GPR88 has a canonical GPCR plasma membrane/cytoplasmic expression, whereas in cortical neurons, we previously reported an atypical …

fr, ca (code pays fourni par la source)

Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment

Vincent Martin, Lionel Mathieu, Jorge Díaz, Haysam Salman et autres

Background: Altered function of serotonin receptor 1A (5-HT1AR) has been consistently implicated in anxiety, major depressive disorder and resistance to antidepressants. Mechanisms by which the function of 5-HT1AR (expressed as an autoreceptor in serotonergic raphe neurons and as a heteroreceptor in serotonin …

us, fr (code pays fourni par la source)

YIF1B mutations cause a post-natal neurodevelopmental syndrome associated with Golgi and primary cilium alterations

Jorge Díaz, Xavier Gérard, Michel Boris Emerit, Julie Areias et autres

Human post-natal neurodevelopmental delay is often associated with cerebral alterations that can lead, by themselves or associated with peripheral deficits, to premature death. Here, we report the clinical features of 10 patients from six independent families with mutations in the autosomal YIF1B …

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Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis

Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Lucie Gorisse-Hussonnois, Florian Rebeillard et autres

fr, us (code pays fourni par la source)

GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes

P. Dutar, Virginie Tolle, Myriam Kervern, Carole Carcenac et autres

fr, it (code pays fourni par la source)

Developmental and adult expression patterns of the G‐protein‐coupled receptor GPR88 in the rat: Establishment of a dual nuclear–cytoplasmic localization

Renaud Massart, Virginie Mignon, Jennifer Stanic, Paola Munoz‐Tello et autres

GPR88 is a neuronal cerebral orphan G-protein-coupled receptor (GPCR) that has been linked to various psychiatric disorders. However, no extensive description of its localization has been provided so far. Here, we investigate the spatiotemporal expression of the GPR88 in prenatal and postnatal …

fr, ca (code pays fourni par la source)

A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels

Michel Boris Emerit, Camille Baranowski, Jorge Díaz, Audrey Martínez et autres

The 5-HT3 receptors are serotonin-gated ion channels that physically couple with purinergic P2X2 receptors to trigger a functional cross-inhibition leading to reciprocal channel occlusion. Although this functional receptor-receptor coupling seems to serve a modulatory role on both channels, this might not be …

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Protein interactome mining defines melatonin MT 1 receptors as integral component of presynaptic protein complexes of neurons

Abla Benleulmi‐Chaachoua, Lina Chen, Kate Sokolina, Victoria Wong et autres

In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled …

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