Xiaodong Pan

Epicardial adipose tissue radiomics predicts VR and MACE after AMI: a prospective cohort study

Zeyan Liu, Yi Yang, Xiaodong Pan, Min Yang et autres

Background: Epicardial adipose tissue (EAT) has been implicated in adverse cardiac remodeling after acute myocardial infarction (AMI), but its imaging-based characterization remains limited. This study was designed to develop and validate EAT radiomics-based models for predicting ventricular remodeling (VR) and major adverse …

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Anterolateral Papillary Muscle Rupture After Acute Myocardial Infarction Leading to Severe Mitral Regurgitation: A Case Report

Zeyan Liu, Shuo Zhou, Xuexiang Li, Qi Yang et autres

Due to dual blood supply, ischemic mitral anterolateral papillary muscle rupture is less common than that of posteromedial papillary muscle and is rare in acute myocardial infarction without left main lesion. "Pseudo-normalization" phenomenon of left ventricular ejection fraction may occur in the …

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Unhealthy lifestyles and low Life’s Essential 8 scores are associated with a higher risk of new-onset low back pain: a prospective cohort study

Zhehao Xiao, Ling Luo, Rui‐Hua Xu, Jiahao Zheng et autres

BACKGROUND CONTEXT: Low back pain (LBP) is a major global public health concern. However, few large-scale prospective cohort studies have comprehensively examined the relationships among multiple modifiable lifestyle factors, cardiovascular health metrics, and LBP risk. PURPOSE: To investigate the associations between healthy …

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Elevated triglyceride-glucose index and its combination with anthropometric indices as indicators of the risk of new-onset transient ischemic attack: a prospective cohort study

Zhehao Xiao, Ling Luo, Weipin Weng, Erhui Yu et autres

BACKGROUND: The association between the triglyceride-glucose (TyG) and combined anthropometric indices with transient ischemic attack (TIA) has not previously been explored in detail. This study investigated the relationship of TyG and anthropometric indices with incident TIA in healthy populations. METHODS: Data from …

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LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia

Qiuyang Zhang, Hsuan Lo, Yue Song, Linjuan Feng et autres

Leucine-rich repeat kinase 2 (LRRK2), primarily expressed in microglia, is responsible for the modulation of innate immune responses and associated with various immunological disorders. Available evidence documents that though as the predominant etiological factor for familial Parkinson’s disease, LRRK2 mutations rarely occur …

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Embankment Long-Term Settlement Prediction Based on Sparse Dictionary Learning

Jian Shen, Bing Duan, Xiaodong Pan

An accurate prediction of long-term embankment settlements is crucial for ensuring road safety and maintaining normal operations. Existing studies have employed inverse analysis of soil parameters based on monitoring data， subsequently updating settlement predictions using the inferred parameters. However， this method is …

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Triglyceride-glucose index, renal function, sleep duration, and myocardial infarction: a UK biobank cohort study

Zeyan Liu, Jinbo Wang, Xiaodong Pan, Pan Zhang et autres

Background: Myocardial infarction (MI) remains a leading cause of cardiovascular morbidity and mortality globally. Insulin resistance, renal function, and sleep duration are key risk factors, yet their combined impact on MI risk is underexplored. Methods: In this UK Biobank cohort study, 415,757 …

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Effects of Obstructive Sleep Apnea on Cognition: An Analysis of Electroencephalography Microstates and Alpha Peak Frequency

Ling Luo, Shaofan Jiang, Xiaodong Pan

BACKGROUND: Respiration-related sleep disorders such as obstructive sleep apnea (OSA) are risk factors for mild cognitive impairment and age-related neurocognitive deficits. Nearly 60% of patients with OSA suffer from a variety of impaired cognitive functions, including attention, working memory, and episodic memory, …

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Cognitive Implications of White Matter Alterations in Overweight Chinese Individuals: An NODDI and DTI Study

Shaofan Jiang, Yingzhe Cheng, Rifeng Jiang, Huang Pei-lin et autres

OBJECTIVE: Scarce studies have elucidated the relationship between the microstructure changes of white matter (WM) and cognitive domains in overweight (OW). This study aimed to evaluate the WM microstructure changes and the relationship with the cognitive domains and cognition-related plasma biomarkers. METHODS: …

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A semi-supervised dual-path model for underground defect detection

Shaoxiang Zeng, G. Wang, Honglei Sun, Yuanqin Tao et autres

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Cognitive implications of white matter microstructural changes in individuals with low heart rate variability: a NODDI study

Shaofan Jiang, Yingzhe Cheng, Ling Luo, Rifeng Jiang et autres

Objective: This study aimed to investigated the microstructural integrity of WM and the relationship with the cognitive domains and cognition-related plasma biomarkers in low heart rate variability (HRV). Methods: Our study recruited 44 high HRV and 44 low HRV (Grouping by median …

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PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

Zhen Wei, Xiaodong Pan, Xiaoli Cui, Jing Zhang et autres

Introduction: Microglial dysfunction is characteristic of Alzheimer's disease (AD), with triggering receptor expressed on myeloid cells 2 (TREM2) and transcription factor PU.1 playing crucial roles. However, the relationship between TREM2 and PU.1 remains unclear. Methods: We investigated TREM2 and PU.1 expression patterns …

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