Fuquan Yang

Combined Inflammatory Burden Index and hand grip strength for prognostic assessment in gastric cancer patients: a multicenter cohort study

Fuquan Yang, Xinyi Wang, Lishuang Wei, Haitao Wen et autres

Background Gastric cancer (GC) is associated with heterogeneous prognosis, and individual inflammatory or nutritional markers have limited predictive value. This study aimed to develop and evaluate a novel grading system integrating the Inflammatory Burden Index (IBI) and handgrip strength (HGS) for prognostic …

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Nutritional-C-reactive protein ratio as a prognostic marker in gastric cancer: a multicenter study

Yibo Chen, Fuquan Yang, changyang chen, Pengyu Chen et autres

Purpose This study aimed to investigate the association of baseline Nutritional-C-reactive Protein Ratio (NCR) with overall survival (OS), severe malnutrition, and cachexia in patients with gastric cancer. Methods Baseline NCR was calculated as BMI (kg/m 2 ) × albumin (g/L) / C-reactive …

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Commentary: PCP4 inhibits the progression of prostate cancer through Ca2+/CAMKK2/AMPK/AR pathway

Wujie Chen, Fajiang Qian, F Wang, Fuquan Yang et autres

10.3389/fimmu.2025.1616046We read with great interest the recent article by Jia and colleagues titled "PCP4 inhibits prostate cancer progression via the Ca²⁺/CAMKK2/AMPK/AR signaling pathway" (1) . In this excellent study, the authors systematically investigated the role of Purkinje cell protein 4(PCP4)(2)in prostate cancer, …

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Receptor-mediated Golgi retention of Fam20 kinases tunes secretome phosphorylation during lactation

Xiaomin Yang, Jueyin He, Xiulan Chen, Xi’e Wang et autres

Fam20C, the first protein kinase identified in the secretory pathway, governs the majority phosphorylation of the secretome. Although Fam20C has a high propensity for secretion, its kinase activity occurs intracellularly. How Fam20C clients are phosphorylated inside cells remains elusive. Here, we demonstrate …

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Adjuvant camrelizumab for hepatocellular carcinoma patients with high risk of recurrence after curative hepatectomy: a retrospective multicenter study

Lei-Po Lin, Jia-Yong Su, Xiao-Feng Dong, Fuquan Yang et autres

BACKGROUND AND AIMS: The role of adjuvant programmed cell death-1 (PD-1) inhibitors following curative hepatectomy in patients with hepatocellular carcinoma (HCC) at high risk of recurrence remains controversial. This study aims to evaluate the efficacy and safety of camrelizumab (a PD-1 inhibitor) …

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Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002)

Da-Long Yang, Chuang Qin, Ning Peng, Shaoping Liu et autres

Hepatectomy is considered advisable for some patients with intermediate or advanced hepatocellular carcinoma (HCC). The efficacy and safety of neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors (neoadjuvant triple therapy) for these patients remain unclear. 583 patients who met the …

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Standardized W-H fundoplication procedure for gastroesophageal reflux disease (2026)

Zhiwei Hu, Jimin Wu, Akbar Ali, Juming Bao et autres

Based on clinical experience and expert consensus from over a hundred medical centers across China, this technical specification systematically establishes a comprehensive operational framework for the standardized W-H fundoplication procedure in gastroesophageal reflux disease (GERD). To address common limitations of conventional techniques, …

Prognostic Usefulness of Clinical Complete Response after PD-1 Inhibitor-Based Combination Therapy for Unresectable Hepatocellular Carcinoma (GUIDANCE006)

Liang Ma, Dalong Yang, Teng-Meng Zhong, Qingqing Pang et autres

Background: Outcomes of patients with unresectable hepatocellular carcinoma (HCC) who achieve clinical complete response (cCR) to PD-1 inhibitor-based combination therapy are unclear. This study aimed to explore whether cCR after combination therapy is an accurate and reliable prognostic indicator and to identify …

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Unveiling Heterogeneity: Innovations and Challenges in Single‐Vesicle Analysis for Clinical Translation

Ying Zhang, Xiaotong Meng, David W. Greening, Yiyao Huang et autres

Extracellular vesicles (EVs) are key mediators of intercellular communication, carrying diverse molecular cargo that reflects the dynamic physiological and pathological state of their source cell. While analyses of the entire vesicular population (bulk EV) have advanced our understanding of their roles in …

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[Progress of PTMomics in type 2 diabetes mellitus and its complications].

X Chen, Fuquan Yang

The growing prevalence of type 2 diabetes mellitus (T2DM) poses a great economic burden on the society. The pathogenesis of T2DM is a combined effect of two factors: defective insulin secretion in pancreatic β cells and peripheral insulin resistance in skeletal muscle, …

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Receptor-mediated mitophagy: a new target of neurodegenerative diseases

Fuquan Yang, Guiyan Chen, Ming Liu, Shiqing Yuan et autres

Neurodegenerative diseases are a category of neurological conditions with high prevalence that pose major treatment challenges. Common pathologies involve protein accumulation and mitochondrial damage. Mitophagy maintains cellular homeostasis by removing defective mitochondria, which are associated with the pathogenesis of neurodegenerative diseases. Although …

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Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang et autres

Mass spectrometry-based peptidomics provides a comprehensive platform for mapping global proteolytic alterations and identifying disease biomarkers. However, existing analytical frameworks often lack the precision to capture disease-specific signatures. Here, a single-position peptide clustering strategy is introduced, leveraging the amino acid score (aa-score) …

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