M. A. Shea

A high time-resolution analysis of the Ground-Level Enhancement (GLE) of 23 February 1956 in terms of the CSHKP standard flare model

K. G. McCracken, M. A. Shea, D. F. Smart

The original real-time analog heritage data from the Huancayo recording ionization chamber is differentiated to yield 15 – 60 second resolution of the first 15 minutes of the cosmic ray Ground-Level Event (GLE) of 23 February 1956. The initial High-Energy Impulsive (HEI) …

Solar Particle Events

M. A. Shea

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Calmodulin binds conserved motifs in fibroblast growth factor homologous factors

Cade R. Rahlf, Ryan W. Mahling, Holly M. Isbell, M. A. Shea

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The regulation of endothelial lipase and lipoprotein lipase by ANGPTL3 and ANGPTL8

Kelli Larissa Davie, Brandon S.J. Davies, Eric B. Taylor, Brian Timothy O'Neill et autres

Low levels of circulating high density lipoproteins (HDL) and high levels of plasma triglycerides (TG) are risk factors for cardiac disease and atherosclerosis. The liver-expressed protein angiopoietin-like 3 (ANGPTL3) regulates both plasma TG and HDL levels through inhibition of lipoprotein lipase (LPL), …

Protein determinants of CLC-ec1 stoichiometry

Kacey N. Mersch, M. A. Shea, Nikolai O. Artemyev, Robert C. Piper et autres

The efforts of this thesis are directed towards understanding the physical driving forces that mediate membrane protein self-assembly processes within the native environment of membrane proteins, the bilayer milieu. While many defined determinants contribute to the energetics of membrane protein self-assembly, such …

Modeling RNA

Robert T. McDonnell, Adrian H. Elcock, Catherine A. Musselman, Miles A. Pufall et autres

Ribonucleic acids (RNAs) are biomolecules involved in a variety of cellular processes facilitated by its inherent ability to adopt diverse structures with unique functions. In many instances, studying RNA structure-function relationships through experimental techniques is an arduous, manually intensive process. By contrast, …

Metabolic regulation of the cardiac sodium channel

Daniel S. Matasic, Barry London, Christopher J. Benson, Charles H Brenner et autres

Sudden cardiac death, an unexpected death by the loss of heart function (cardiac arrest), is a major health problem in the United States and in the rest of the world, accounting for 50% of all heart disease-related deaths and 15%-20% of all …

NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD

Ryan W. Mahling, Liam Hovey, Holly M. Isbell, Dagan C. Marx et autres

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Ca2+-saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors

Ryan W. Mahling, Cade R. Rahlf, Samuel C. Hansen, Matthew R. Hayden et autres

Voltage-gated sodium channels (Na v s) are tightly regulated by multiple conserved auxiliary proteins, including the four fibroblast growth factor homologous factors (FGFs), which bind the Na v EF-hand like domain (EFL), and calmodulin (CaM), a multifunctional messenger protein that binds the …

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Recognition of NaV1.2 by calmodulin and fibroblast growth factor homologous factors

Ryan W. Mahling, M. A. Shea, Peter A. Rubenstein, Ernesto J. Fuentes et autres

The voltage-gated sodium channel 1.2 (NaV1.2) is a transmembrane protein primarily expressed in the central nervous system where it is responsible for generating the rising phase of an action potential. To do this, NaV1.2 undergoes voltage-dependent conformational changes that transition the pore …

RAD6-18 interactions with translesion synthesis polymerases, Pol H and Rev1

Brittany M. Ripley, M. A. Shea, Maria Spies, Robert C. Piper et autres

DNA damage blocks the replication fork, which can result in fork collapse, single stranded breaks, and ultimately cell death. Translesion synthesis (TLS) is a pathway by which a special set of DNA polymerases, which include Rev1 and Pol η, are recruited to …

MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII

Klitos Konstantinidis, Vassilios J. Bezzerides, Lo Lai, Holly M. Isbell et autres

Oxidant stress can contribute to health and disease. Here we show that invertebrates and vertebrates share a common stereospecific redox pathway that protects against pathological responses to stress, at the cost of reduced physiological performance, by constraining Ca2+/calmodulin-dependent protein kinase II (CaMKII) …

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