Cinzia Pizzirani

Randomized Phase II/III Trial Of 3 Vs 6 Courses Of Neoadjuvant Carboplatin-Paclitaxel Chemotherapy In Stage IIIC Or IV Epithelial Ovarian, Fallopian Tube Or Primary Peritoneal Carcinoma

Claudio Zamagni, Anna Fagotti, Daniela Rubino, Vanda Salutari et autres

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Three-monthly dynamic evaluation of CEA and CA15-3 and 18-FDG PET vs usual practice in the follow-up of early breast cancer patients: a prospective, multicenter, randomized trial (KRONOS – Patient-Oriented New Surveillance-Study Italy)

Elena Barbieri, María Gión, Luigi Mariani, P Stieber et autres

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CEA, CA15.3 and 18-FDG PET in the follow-up of early breast cancer (BC) patients (pts): A prospective, multicentric, randomized trial—KRONOS patient-oriented new surveillance study Italy.

Claudio Zamagni, Massimo Gion, Luigi Mariani, P Stieber et autres

TPS11627 Background: Current recommendations for breast cancer (BC) surveillance in asymptomatic patients (pts) include only mammography and physical examination and arise from two trials conducted in the 80’s. Since then new findings about BC biology, treatment and the introduction of cutting-edge diagnostic …

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Abstract OT3-05-01: Three-monthly dynamic evaluation of CEA and CA15-3 (followed by 18-FDG PET) vs usual practice in the follow-up of early breast cancer (BC) patients (pts): A prospective randomized trial (KRONOS-patient-oriented new surveillance study, Italy)

Claudio Zamagni, María Gión, Luigi Mariani, P Stieber et autres

Abstract Background: Current guidelines for BC surveillance in asymptomatic pts recommend annual mammography and periodical physical examination. These recommendations arise from two trials conducted in the 1980's: since then no other randomized controlled trials (RCTs) have been conducted on BC follow-up. However …

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Processing and Release The P2X7 Receptor: A Key Player in IL-1

Antonio Curti, Marco Idzko, Elisabeth Panther, Davide Ferrari et autres

Francesco Di VirgilioLemoli, Antonio Curti, Marco Idzko, Elisabeth Panther and Davide Ferrari, Cinzia Pizzirani, Elena Adinolfi, Roberto M.http://www.jimmunol.org/content/176/7/3877J Immunol€2006; 176:3877-3883; ;Referenceshttp://www.jimmunol.org/content/176/7/3877.full#ref-list-1This article cites 89 articles, 47 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology …

IL‐18 associates to microvesicles shed from human macrophages by a LPS/TLR‐4 independent mechanism in response to P2X receptor stimulation

Sara Gulinelli, Erica Salaro, Marta Vuerich, Dania Bozzato et autres

Extracellular ATP, released upon microbial infection, cell damage, or inflammation, acts as an alert signal toward immune cells by activating P2 receptors. The nucleotide causes microvesicle (MV) shedding from immune and nonimmune cells. Here, we show that IL-18 associates with MVs shed …

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Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra

Matteo Colina, Cinzia Pizzirani, M. N. M. KHODEIR, Simonetta Falzoni et autres

Sir, The syndrome of Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) is a rare condition characterized by a variable combination of osteoarticular and cutaneous manifestations [1]. Although often related to the SpAs, emerging evidence suggests that SAPHO might be a primitive inflammatory osteitis, …

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Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation

Davide Ferrari, Paolo Pinton, Michelangelo Campanella, Maria Giulia Callegari et autres

C(2)-ceramide (C(2)-cer) and binding of the CD95/APO-1/FAS (aCD95) receptor are acknowledged inducers of apoptosis. In spite of that, their effects on the endoplasmic reticulum (ER) and mitochondria during early phases of apoptotic onset are poorly characterized. Here, by employing various approaches, we …

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Dysfunctional inflammasome in Schnitzler's syndrome

Cinzia Pizzirani, Simonetta Falzoni, Marcello Govoni, R. L. Corte et autres

OBJECTIVE: IL-1beta plays a key role in the pathogenesis of Schnitzler's syndrome (SS). We have investigated inflammasome activity in peripheral blood mononuclear cells (PBMCs) from a patient affected by a variant type of SS. METHODS: PBMCs were purified by Ficoll and examined …

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The Human Cathelicidin LL-37 Modulates the Activities of the P2X7 Receptor in a Structure-dependent Manner

Linda Tomasinsig, Cinzia Pizzirani, Barbara Skerlavaj, Patrizia Pellegatti et autres

Extracellular ATP, released at sites of inflammation or tissue damage, activates the P2X(7) receptor, which in turn triggers a range of responses also including cell proliferation. In this study the ability of the human cathelicidin LL-37 to stimulate fibroblast growth was inhibited …

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Stimulation of P2 (P2X 7 ) receptors in human dendritic cells induces the release of tissue factor‐bearing microparticles

Marcello Baroni, Cinzia Pizzirani, Mirko Pinotti, Davide Ferrari et autres

ABSTRACT Receptors for extracellular nucleotides are the focus of increasing attention for their ability to cause release of plasma membrane vesicles (micropar‐ticles, MPs). Here, we show that monocyte‐derived human dendritic cells (DCs) stimulated with a P2X 7 receptor (P2X 7 R) agonist …

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Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule

Davide Ferrari, Cinzia Pizzirani, Sara Gulinelli, Giulia Callegari et autres

BACKGROUND AND PURPOSE: P2X7 is a membrane receptor for extracellular ATP which is highly expressed in dendritic cells, macrophages and microglia where it mediates pro-inflammatory responses. The antibiotic polymyxin B, which binds to and neutralizes the toxic residue of bacterial lipopolysaccharide, greatly …

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