Dongfei Ma

MonoXtract: A Deep Learning Framework for Extracting Transmembrane Protein Dynamics from Single-Color Single-Molecule Imaging

Xiang Li, Chenguang Yang, Chen Lin, Hao Wang et autres

Abstract Single-color fluorescence-based single-molecule techniques enable label-efficient probing of membrane-associated biomolecular dynamics. However, extracting reliable kinetic information is challenging due to signal heterogeneity, noise and the absence of reference channels. Here, we introduce MonoXtract (Single-color fluorescence Trajectory eXtraction and Analysis via Transformer …

cn, se (code pays fourni par la source)

Optimal fidelity-cost trade-off in DNA polymerase proofreading

Qi Jia, Qiushi Li, Hang Fu, H WANG et autres

cn (code pays fourni par la source)

Protonation-Regulated Membrane-Insertion Dynamics of pH Low-Insertion Peptide: Metastable Molecular Conformations and Their Transitions

Jie Qiu, Dongfei Ma, Xin You, Qi Jia et autres

The pH-triggered structural transition and translocation of the pH low-insertion peptide (pHLIP) across cell membranes, facilitated by its distinct protonation property, render it a valuable model for investigating the membrane insertion mechanism of molecules. This capability also holds significant promise for advancements …

cn, cz (code pays fourni par la source)

Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane

Xin Jiang, Chenguang Yang, Jie Qiu, Dongfei Ma et autres

LL-37, the only human host cathelicidin peptide, is proposed to be able to induce host cell apoptosis through mitochondrial membrane permeabilization (MMP). Detailed pathways of the LL-37-triggered MMP are however still disputed. It is generally believed that cationic peptides permeate a membrane …

cn (code pays fourni par la source)

Correction: Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane

Xin Jiang, Chenguang Yang, Jie Qiu, Dongfei Ma et autres

Correction for ‘Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane’ by Xin Jiang et al. , Nanoscale , 2022, https://doi.org/10.1039/d2nr05409d.

cn (code pays fourni par la source)