Calum Yacoubian

Agentic AI in Healthcare: Opportunities, Challenges, and Future Directions

Mourad Gridach, Jay Nanavati, Khaldoun Zine El Abidine, Calum Yacoubian et autres

The integration of Agentic AI into healthcare marks a new era in medical automation and decision support. Leveraging autonomous reasoning, planning, and collaboration, these AI systems are transforming clinical workflows, diagnostics, and patient management. Recent advancements have led Agentic AI to evolve …

gb (code pays fourni par la source)

A data-driven architecture using natural language processing to improve phenotyping efficiency and accelerate genetic diagnoses of rare disorders

Jignesh R. Parikh, Casie A. Genetti, Asli Aykanat, Catherine A. Brownstein et autres

Effective genetic diagnosis requires the correlation of genetic variant data with detailed phenotypic information. However, manual encoding of clinical data into machine-readable forms is laborious and subject to observer bias. Natural language processing (NLP) of electronic health records has great potential to …

us, Kenya (code pays fourni par la source)

Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation

Michelle M. Clark, Amber Hildreth, Serge Batalov, Yan Ding et autres

By informing timely targeted treatments, rapid whole-genome sequencing can improve the outcomes of seriously ill children with genetic diseases, particularly infants in neonatal and pediatric intensive care units (ICUs). The need for highly qualified professionals to decipher results, however, precludes widespread implementation. …

us, gb, ch (code pays fourni par la source)

The role of calculated non-caeruloplasmin-bound copper in Wilson’s disease

Andrew Duncan, Calum Yacoubian, Robert Beetham, Anthony Catchpole et autres

Background US and European guidelines suggest the use of calculated non-caeruloplasmin-bound copper (free copper index) for the diagnosis and management of Wilson's Disease. However, there is concern that the required analytical measurements of caeruloplasmin and copper may not be sufficiently robust at …

gb (code pays fourni par la source)

The risk of copper deficiency in patients prescribed zinc supplements

Andrew Duncan, Calum Yacoubian, Neil Watson, Ian Morrison

AIMS: In high doses zinc may cause copper deficiency, a diagnosis that is often missed resulting in anaemia, neutropenia and irreversible neurological symptoms. The aim of this study was to assess if zinc deficiency is erroneously diagnosed by misinterpretation of plasma zinc …

gb (code pays fourni par la source)

The risk of copper deficiency in patients prescribed zinc supplements: Table 1

Andrew Duncan, Calum Yacoubian, Neil Watson, Ian Morrison

MRI ‐based abnormalities in young adults at risk of adverse bone health due to childhood‐onset metabolic & endocrine conditions

Christie McComb, A. Harpur, Calum Yacoubian, Cheryl L. Leddy et autres

OBJECTIVE: Traditional methods of bone densitometry may not provide a comprehensive assessment of bone health. We aimed to assess bone micro-architecture and bone marrow adiposity (BMA) by MRI in adults with osteogenesis imperfecta (OI) and endocrinopathy including GH deficiency and/or hypogonadism. MEASUREMENTS: …

gb (code pays fourni par la source)

Diagnostic yield in chondrodysplasias: a single centre study between 2002 and 2012

Calum Yacoubian, S. Faisal Ahmed, Esther Kinning

The assessment of bone microarchitecture by high resolution magnetic resonance imaging (micro MRI) in young adults with childhood onset disease

Calum Yacoubian, Christie McComb, Christopher Leddy, Faisal Awad Ahmed et autres