Christopher D. Willey

MARCKS as a mediator and target for pathological tunneling nanotubes between patient-derived glioblastoma cells and astrocytes

Lauren Nassour, Mayada Ahmed, Shane T. Rich-New, Taylor L. Schanel et autres

During glioblastoma (GBM) progression, therapeutic resistance is influenced by a heterogeneous network of tumor- and tumor-promoting subpopulations within the tumor microenvironment. Therapeutic interventions against tumor cells, such as chemoradiotherapy, can further induce adaptive defense mechanisms mediated by sophisticated intercellular communication and aberrant …

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CD8 immunoPET imaging to stratify response and guide combination immunotherapy and radiation in triple negative breast cancer

Patrick N. Song, Chloe T. DeMellier, Shannon E. Lynch, Carlos A. Gallegos et autres

PURPOSE: PET imaging targeting immune cells can be used to dynamically monitor intratumoral immune modulation in tissues. Radiation therapy is known to alter the tumor immune microenvironment; therefore, this study demonstrates how CD8 immunoPET imaging can optimize combination immunotherapy and radiation therapy …

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Abstract 7001: Tumor-intrinsic suppression of phagocytosis by RRP1 (ribosomal RNA processing 1) in glioblastoma

E. Kudaravalli, Amr Elkholy, Mostafa Mohamed, Hasan Alrefai et autres

Abstract Glioblastoma (GBM) is the most aggressive and common malignant brain tumor in adults, with a median survival of just 14.6 months. Standard treatment, comprising maximal surgical resection followed by radiation and temozolomide, offers limited long-term benefit, highlighting the urgent need for …

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Abstract 3306: The role of DDR1 ectodomain shedding in glioblastoma radiation resistance

S Dunlap, Caitlin A. Harvey, Christopher D. Willey, Ahn Erin

Abstract Introduction: Glioblastoma (GBM) is the most common malignant brain tumor in adults, and resistance to radiation therapy remains a major therapeutic obstacle. Although genetic alterations contribute to GBM progression, they do not fully explain the emergence of radiation resistance, suggesting contributions …

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Abstract 7017: EMP2 is a potential immunotherapeutic target to modulate macrophage-induced phagocytosis in glioblastoma

Amr Elkholy, E. Kudaravalli, Mostafa Mohamed, Hasan Alrefai et autres

Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor. Despite advances in immunotherapy for other solid tumors, T-cell checkpoint blockades have failed to improve overall survival in GBM patients, largely due to low T-cell infiltration. In contrast, tumor-associated macrophages (TAMs) comprise …

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Abstract 5878: Tumor Treating Fields remain effective in therapy-resistant glioblastoma with kinome shifts revealing novel therapeutic opportunities

Taylor Lynn Schanel, Amber Jones, Rhea Pandit, Johsua C. Anderson et autres

Abstract Glioblastoma (GBM) is the most common primary brain tumor in adults with a median survival of less than 15 months with maximal safe surgical resection, radiation, and the chemotherapy temozolomide. Addition of Tumor Treating Fields (TTFields), or alternating electromagnet fields therapy, …

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Randomized, double-blind, sham-controlled trial of an intraoral photobiomodulation device for oral mucositis due to radiotherapy for head and neck cancer

Kenneth H. Hu, Pratish Shah, M. Connie Nguyen, Cornelia McCluskey et autres

Abstract Purpose This study evaluated the safety and effectiveness of an intraoral light-emitting diode (LED)-based photobiomodulation (PBM) device to reduce the incidence and severity of oral mucositis (OM) from intensity modulated radiation therapy (IMRT) for head and neck cancer (HNC). Methods This …

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MARCKS as a Target for Pathological Tunneling Nanotubes in Glioblastoma

Christopher D. Willey, Lauren Nassour, Mayada Ahmed, Shane T. Rich-New et autres

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Biomedical Data Manifest: A lightweight data documentation mapping to increase transparency for AI/ML

Daniel Bottomly, Christopher G. Suciu, Benjamin Cordier, Nathaniel Evans et autres

Biomedical machine learning (ML) models raise critical concerns about embedded assumptions influencing clinical decision-making, necessitating robust documentation frameworks for datasets that are shared via external repositories. Fairness-aware algorithm effectiveness hinges on users' prior awareness of specific issues in the data - information …

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Short‐Term Outcomes of Advanced Pneumatic Compression Device Versus Usual Care Therapy for Head and Neck Cancer‐Related Lymphedema: A Multi‐Site Randomized Clinical Trial

Barbara A. Murphy, Derek K. Smith, Cristina M. Kline‐Quiroz, K. S. Jensen et autres

BACKGROUND: Two-month outcomes of advanced pneumatic compression device (APCD) and usual care (UC) in Head and Neck Cancer survivors with previously untreated lymphedema were compared. METHODS: Participants in this multisite, randomized clinical trial were randomized to APCD or UC. The primary endpoint …

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The effect of timing of post-operative radiation on outcomes in anaplastic thyroid cancer

Andrew B. Bonner, Herbert Chen, Sharon A. Spencer, Christopher D. Willey et autres

BACKGROUND: Anaplastic thyroid cancer is an aggressive malignancy, for which prompt treatment is necessary. Surgical resection is the recommended initial treatment for resectable cases and most patients require postoperative radiation therapy (PORT). NCCN Guidelines state that adjuvant radiation should ideally begin 2–3 …

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AI-based framework to fuse pre-RT brain metastases contours with follow-up MRI to improve post-RT assessment

Yogesh Kumar, H. H. Chang, Udbhav S Ram, Gaurav N. Rathi et autres

Background: Brain metastases (BMs) patients often receive multiple courses of radiotherapy (RT). Comparing follow-up imaging with RT plans is time-intensive and currently not possible in picture archiving and communication system (PACS). In this study, we aim to develop an automated tool to …

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