K.L. Shires

The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease

Roger A. Barker, Nicholas P Lao–Kaim, Natalie Valle Guzman, Dilan S. Athauda et autres

Abstract Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial ( NCT01898390 ) was designed to determine whether this approach could be further …

gb, se (code pays fourni par la source)

The relationship between tetanus intensity and the magnitude of hippocampal long-term potentiation in vivo

Stephen J. Martin, K.L. Shires, Patrick A. Spooner

In this study, we assessed the effects of varying tetanus and test-pulse intensity on the magnitude of long-term potentiation (LTP) in the perforant path-dentate gyrus projection of urethane-anaesthetized rats. We developed a novel within-subjects procedure in which test-pulse-stimulation intensity (60-1000 μA) was …

gb (code pays fourni par la source)

Synaptic tagging and capture in the living rat

K.L. Shires, B.M. Da Silva, J.P. Hawthorne, Richard Morris et autres

gb (code pays fourni par la source)

Postsubiculum and memory: the effects of postsubicular AMPA and NMDA receptor bloackade on spatial and non-spatial recognition memory in rats

Cassie Hosburn, K.L. Shires, David Bett, J.P. Hawthorne et autres

Using IEG's to uncover pathways for spatial learning in the rat.

K.L. Shires

This thesis concentrates on the induction of the immediate early genes zif268 and c-fos in a functional and dysfunctional brain network. Initial studies focused on the creation of a task to allow the study of immediate early gene activation after working memory. …