Lijun Ning

Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza

Li Li, Manjing Jiang, Wei Hong, Linpan Liang et autres

Scutellariae Radix (SR) is widely used in Chinese medicine for influenza treatment; however, the mechanisms underlying its effect remain unknown. Here, we report, for the first time, that the therapeutic effects of SR on influenza involve regulation of antiviral interferons (IFNs), type …

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IAV NS1 carried by exosomes promotes IL-10 production by the PI3K-AKT-GSK3β-CREB pathway

Huimin Huang, Hua Yang, Yan-chun Qin, Jian-Yu Luo et autres

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Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype

Muni Hu, Xiaoqiang Zhu, Xiaowen Huang, Hua Li et autres

Immunotherapy has revolutionized cancer treatment, but response variability remains a challenge. The gut microbiome's role in therapeutic efficacy is well established, but the impact of the gut mycobiome is less understood. Using unsupervised clustering, we identify two gut mycobiome-based enterotypes, favorable type …

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Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease

Yuqing Yan, Li Tian, Ying Zhao, Baoqin Xuan et autres

BACKGROUND AND AIMS: Bacteroides fragilis toxin (BFT), produced by enterotoxigenic B. fragilis (ETBF), is crucial for ETBF-induced colitis. This study aims to investigate the impact of BFT-host interactions on N6-methyladenosine (m6A) modification of host mRNA and its underlying mechanisms. METHODS: Single-cell sequencing …

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Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease

Zhenyu Wang, Tian Li, Yi Jiang, Lijun Ning et autres

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Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses

Xiaoqiang Zhu, Muni Hu, Xiaowen Huang, Lingxi Li et autres

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Baicalin Modulates Glycolysis via the PKC/Raf/MEK/ERK and PI3K/AKT Signaling Pathways to Attenuate IFN‐I‐Induced Neutrophil NETosis

Li Li, Linpan Liang, Lijun Ning, Ying Wu

Type I interferon (IFN‐I), a pivotal component of the host’s innate antiviral immune system, can induce the formation of neutrophil extracellular traps (NETs) and facilitate inflammatory responses. Baicalin exhibits a range of pharmacological activities, including anti‐inflammatory and immunomodulatory effects. It has been …

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Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy

Lijun Ning, Jie Hong

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A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy

Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Rongrong Sun et autres

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Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

Lijun Ning, Yilu Zhou, Han Sun, Youwei Zhang et autres

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. To address …

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Multi-kingdom gut microbiota analyses define bacterial-fungal interplay and microbial markers of pan-cancer immunotherapy across cohorts

Xiaowen Huang, Muni Hu, Tiantian Sun, Jiantao Li et autres

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Publisher Correction: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer

Xinyuan Wang, Yujie Zhou, Lijun Ning, Huimin Chen et autres

Due to a technical problem the uncorrected proof has been published online. The online PDF version of this article has been updated now.

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