Simona Cosconea

2348P Early impact of a pilot multimodal personalized early cancer detection and prevention program for lynch syndrome patients

Thomas Pudlarz, Tarek Ben Ahmed, Lucie Véron, Pamela Abdayem et autres

fr (code pays fourni par la source)

Collagenous colitis in patients treated for cancer: role of immune checkpoint inhibitors. Clinical, histological and immunological features in 15 cases

Mohamed Amine Bani, Peggy Dartigues, Ranya Soufan, Simona Cosconea et autres

BACKGROUND AND AIMS: Collagenous colitis is a rare complication of immunotherapy for cancer. We report here 15 cases in order to assess the role of immune checkpoint inhibitors (ICI) in the onset of this disease, describe the histopathological and immunological features of …

fr (code pays fourni par la source)

Clinical and molecular features of early onset pancreatic adenocarcinoma

Maxime Rémond, Cristina Smolenschi, Anthony Tarabay, Maximiliano Gelli et autres

Pancreatic adenocarcinoma (PDAC) is a major health burden and may become the second cause of death by cancer in developed countries. The incidence of early-onset pancreatic cancer (EOPC, defined by an age at diagnosis <50 years old) is increasing. Here, we conducted …

fr (code pays fourni par la source)

Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer

Alice Boilève, Jérôme Cartry, Negaar Goudarzi, Sabrina Bedja et autres

Background Patient-derived organoids (PDO) are promising tumor avatars that could enable ex vivo drug tests to personalize patients' treatment in the frame of functional precision oncology (FPM). Yet, clinical evidence remain scarce. This study aims to evaluate whether PDO can be implemented …

fr (code pays fourni par la source)

Are endoscopic findings clinically significant in case of 18F-FDG-PET incidental uptakes of the gastrointestinal tract in cancers patients ? A multicentric rétrospective study

Yanis Dahel, Élise Meunier, Christophe Zemmour, Rémi Palmier et autres

Aims Gastrointestinal tract (GIT) incidental uptakes on 18-fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is a common situation leading to endoscopic investigation potentially useless in cancer patients. In these patients and because endoscopic findings can be clinically relevant, we need precise criteria to help …

fr, cl (code pays fourni par la source)

Codon-specific KRAS mutations predict survival in advanced pancreatic cancer

Alice Boilève, Adrien Rousseau, Marc Hilmi, Anthony Tarabay et autres

Background How distinct KRAS alterations in pancreatic adenocarcinoma (PDAC) influence tumor initiation and outcomes remains unclear. Moreover, KRAS is now partly targetable with novel specific inhibitors targeting KRAS G12 (G12C or G12D), but specific outcomes of these subgroups of patients is poorly …

fr, us (code pays fourni par la source)

High coffee consumption is not associated with less liver fibrosis in non-alcoholic steato-hepatitis: Results of the COCANASH study

Hugues Blondon, Marc Delord, Simona Cosconea, Simona Tirziu et autres

fr (code pays fourni par la source)

1667P Clinical and molecular features of young onset pancreatic adenocarcinoma

Marc Gerard Wootton Rémond, Anthony Tarabay, Antoine Hollebecque, Maximiliano Gelli et autres

fr (code pays fourni par la source)

112P Clinical, genomic and transcriptomic characteristics of young-onset biliary tract cancers

Thomas Pudlarz, Lina Antoun, Antoine Rousseau, R. Nicolle et autres

fr (code pays fourni par la source)

Precision Medicine in Pancreatic Ductal Adenocarcinoma: The Impact of Targeted Therapies on Survival of Patients Harboring Actionable Mutations

Anthony Tarabay, Alice Boilève, Cristina Smolenschi, Leony Antoun et autres

Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of death by cancer worldwide. Mostly diagnosed with locally advanced or metastatic disease, patients lack treatment options. Gene alterations (GAs) are frequently observed in PDAC, some of which are considered for molecular …

fr (code pays fourni par la source)

Precision Medicine in Pancreatic Ductal Adenocarcinoma: The Impact of Targeted Therapies on Survival of Patients Harboring Actionable Mutations

Anthony Tarabay, Alice Boilève, Cristina Smolenschi, Leony Antoun et autres

Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of death by cancer worldwide. Mostly diagnosed with locally advanced or metastatic disease, patients lack treatment options. Gene alterations (GAs) are frequently observed in PDAC; some of which are considered for molecular …

fr (code pays fourni par la source)

Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography

Thomas Deffieux, Jean‐Luc Gennisson, Laurence Bousquet, Marion Corouge et autres

fr (code pays fourni par la source)