Marius Cadar

Effectiveness of oral anticoagulants in precapillary pulmonary hypertension associated with systemic sclerosis: a EUSTAR cohort study

Nicola Farina, Silvia Bellando Randone, Hilde Jenssen-Bjørkekjær, Sébastien Sanges et autres

OBJECTIVES: The role of anticoagulation in systemic sclerosis (SSc) with precapillary pulmonary hypertension (PH) remains controversial, with conflicting evidence regarding its impact on survival, including potential harmful effects. Aiming to address this research gap, we evaluated both mortality and PH worsening in …

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Diagnostic accuracy of lung ultrasound for the detection of interstitial lung disease in rheumatoid arthritis: a systematic review and meta-analysis

D. M. Reza Beigi, Greta Pellegrino, Marco Davide Dal Fabbro, Marius Cadar et autres

To evaluate the diagnostic accuracy of lung ultrasound (LUS) for detecting rheumatoid arthritis-associated interstitial lung disease (RA-ILD), using high-resolution computed tomography (HRCT) as the reference standard. A systematic review and diagnostic test accuracy meta-analysis was conducted according to PRISMA-DTA. PubMed, Embase, Scopus, …

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Selexipag in SSc-associated pulmonary arterial hypertension: long-term real-world data from a multicentre Italian cohort

Stefano Stano, Claudia Iannone, Corrado Campochiaro, Marco Vicenzi et autres

OBJECTIVES: Pulmonary arterial hypertension (PAH) is a life-threatening complication of SSc. Although selexipag is approved for SSc-PAH, available data are limited. We evaluated the long-term safety and clinical predictors associated with selexipag therapy in a multicentre Italian cohort of SSc-PAH patients. METHODS: …

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Diagnostic performance of lung ultrasound for systemic sclerosis-associated interstitial lung disease: an international cross-sectional study from two tertiary care centers

D. M. Reza Beigi, Jesús Loarce-Martos, Greta Pellegrino, Nicholas Landini et autres

OBJECTIVE: To assess the diagnostic accuracy of two lung ultrasound (LUS) scores (≥ 10 B-lines and pleural line abnormalities according to Fairchild's criteria) for detecting interstitial lung disease (ILD) in systemic sclerosis (SSc), when applied independently at two referral centers using a …

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P.276 Immunosuppressive therapy persistence in systemic sclerosis: the role of anti-centromere antibodies

Martina Salerno, Marius Cadar, Ilaria Bisconti, Francesca Romana Di Ciommo et autres

Introduction Anti-centromere antibodies (ACA) identify a distinct subset of systemic sclerosis (SSc) patients, traditionally associated with a less fibrotic phenotype and higher vascular risk. Their impact on immunosuppressive (IS) therapy persistence has not yet been clarified. The aim of this study is …

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P.097 Quantitative CT phenotyping and biomarker signatures in systemic sclerosis-associated interstitial lung disease

D. M. Reza Beigi, Giuseppe Ocone, Greta Pellegrino, Nicholas Landini et autres

Introduction Identifying distinct radiological phenotypes in systemic sclerosis-associated interstitial lung disease (SSc-ILD), namely a predominantly inflammatory and a predominantly fibrotic pattern, may capture disease heterogeneity and support therapeutic decisions. Automated quantitative CT (qCT) provides reproducible, operator-independent quantification of ILD and ILD-related features …

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P.203 The burden of calcinosis cutis on peripheral vascular involvement in systemic sclerosis: data from the Italian spring registry

Marius Cadar, Greta Pellegrino, Fabrizio Conti, Clodoveo Ferri et autres

Introduction Calcinosis cutis (CC) is a frequent symptom of systemic sclerosis (SSc) and it is associated with vascular involvement, although its actual relationship, direct manifestation or consequence, with the underlying disease remain unclear. This study aimed to evaluate the possible impact of …

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P.128 Real-life effectiveness of Selexipag treatment in systemic sclerosis associated pulmonary arterial hypertension: long-term data from a multicentric Italian cohort

Stefano Stano, Fabio Cacciapaglia, Mariangela Nivuori, Corrado Campochiaro et autres

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P.380 Microvascular involvement in idiopathic inflammatory myositis: capillaroscopic study in a single-center cohort of patients with dermatomyositis and antisynthetase syndrome

Jacopo Landro, D. M. Reza Beigi, Ilaria Bisconti, Marius Cadar et autres

Introduction Dermatomyositis (DM) and antisynthetase syndrome (ASyS) are idiopathic inflammatory myopathies (IIM) with an autoimmune pathogenesis, where microvascular abnormalities play a central role. Such changes can be detected through skin and muscle biopsies as well as typical cutaneous manifestations, such as heliotrope …

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Comparison of quantitative lung ultrasound scores with automated quantitative CT: to overcome the ultrasound limitations

D. M. Reza Beigi, Greta Pellegrino, Nicholas Landini, M. Diana et autres

OBJECTIVES: Lung ultrasound (LUS) is emerging as a valuable tool for assessing systemic sclerosis-associated interstitial lung disease (SSc-ILD), although it traditionally explores only superficial lung regions. Building upon our preliminary findings, this study investigated correlations between quantitative LUS scores and automated quantitative …

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POS0967 LUNG ULTRASOUND FOR SYSTEMIC-SCLEROSIS ASSOCIATED INTERSTITIAL LUNG DISEASE DETECTION: A BI-CENTER INTERNATIONAL RETROSPECTIVE REAL-LIFE STUDY

D. M. Reza Beigi, J. Loarce-Martos, Greta Pellegrino, Nicholas Landini et autres

Background: Lung ultrasound (LUS) has emerged as a promising non-invasive, radiation-free tool for detecting systemic sclerosis-associated interstitial lung disease (SSc-ILD) [1]. Key LUS findings for ILD include B-lines and pleural line irregularity (PLI), with formal definitions recently established by OMERACT [2]. Several …

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Comparison of Lung Ultrasound B-Lines and Pleural Line Alterations with Automated Quantitative CT: Is it Possible to Overcome the Limitations of the Ultrasound Method?

D. M. Reza Beigi, Greta Prellegrino, Nicholas Landini, Monica Mattone et autres

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