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Arianna Scuteri, E Donzelli, R Rigolio, E Ballarini et autres
Multiple Sclerosis (MS) is a crippling chronic disease of the Central Nervous System caused by the presence of self-antibodies which progressively damage axonal myelin sheath, leading to axonal transmission impairment and to the development of neurological symptoms. MS is characterized by a …
R Rigolio, P Marmiroli, Guido Cavaletti, Rodríguez Menéndez et autres
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Magnetic Resonance Imaging (MRI), showing the extent of the involvement of CNS, plays a major role in the assessment of patients with MS. Further information can be …
Guido Cavalletti, Gabriella Nicolini, C Ceresa, N Oggioni et autres
Organic cation transporters (OCTs) play an important role in transporting cationic xeno- and endobiotics across biological membranes. In particular their role in platinum drugs transport, such as cisplatin and oxaliplatin, has recently been studied in many normal tissues and cancer cells. It …
R Rigolio, Massimiliano Cadamuro, Grazia Caramia, Alessio Malacrida et autres
Cholangiocarcinoma (CCA) is the second most frequent primary liver neoplasia. It mainly arises from the malignant transformation of biliary epithelial cells, although it might originate from either hepatic progenitor cells at the Hering canals or transformed hepatocytes. CCA is a highly aggressive …
E Donzelli, Gabriella Nicolini, Arianna Scuteri, Valentina De Cristofaro et autres
Oxygen and glucose deprivation (OGD) due to ischemic events or trauma in the brain result in neuronal loss. The therapeutic approaches available inadequate and often the outcome is unfavorable for the patient or at least unpredictable. Stem cells could be useful for …
Giacomo E. Barbone, C Ceresa, Marianna Monfrini, Marina Eckermann et autres
X-ray phase contrast micro-tomography (μPCI-CT) is a high resolution technique that can be used to investigate vascular and neurodegenerative disorders overcoming the limitations of the conventional imaging modalities. In fact, currently available neuroimaging techniques are based on sample-invasive imaging protocols involving dissections, …
Alessio Malacrida, Marie Deschamps-Wright, R Rigolio, Guido Cavaletti et autres
In the original publication [...].
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Jacopo Ronchi, R Rigolio, Davide M Trevisan, Angela Papagna et autres
ABSTRACT Autoimmune diseases (AIDs) arise from complex immune dysregulations involving multiple immune cell types, cytokines, and molecular mediators. Among these, microRNAs (miRNAs) have recently emerged as key regulators of leukocyte processes and are frequently dysregulated in AIDs. However, their role in disease …
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M. Ceccon, Maria Elena Boggio Merlo, L. Mologni, Teresa Poggio et autres
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Martina Giambra, Andrea Di Cristofori, Francesca Raimondo, R Rigolio et autres
The vacuolar proton-translocating ATPase (V-ATPase) is a transmembrane multi-protein complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role is crucial since the metabolism underlying carcinogenesis is mainly based on anaerobic glycolytic reactions. Moreover, neoplastic cells use the …
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Martina Giambra, Andrea Di Cristofori, Francesca Raimondo, R Rigolio et autres
The vacuolar proton translocating ATPase (V-ATPase) is a transmembrane multi-protein complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role is crucial since the metabolism is mainly based on anaerobic glycolytic reactions. Moreover, the neoplastic cells use the …
it (code pays fourni par la source)
Alessio Malacrida, Marie Deschamps-Wright, R Rigolio, Guido Cavaletti et autres
Rigosertib is a small molecule in preclinical development that, due to its characteristics as a dual PLK1 and PI3K inhibitor, is particularly effective in counteracting the advance of different types of tumors. In this work, we evaluated the efficacy of Rigosertib and …
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