Kriti Kashyap

Environmentally Benign Synthesis, Characterization, and Computational Studies of a Bidentate, Potentially Nonlinearly Optical Schiff Base and Its Transition Metal Complexes

Ekta Kundra Arora, Kriti Kashyap, Vibha Sharma, Yogita Yogita et autres

ABSTRACT Schiff bases are a significant group of synthetic molecules with widespread applications because they can form stable metal complexes, with conjugated Schiff bases possessing tuneable opto‐electronic properties. Conventional Schiff base syntheses often utilize harsh chemicals and conditions; therefore, an environmentally benign …

in (code pays fourni par la source)

MFSD8 ‐Related CLN7 Disease with Adult‐Onset Cerebellar Ataxia: A Five‐Patient Case Series

Pooja Sharma, Ayush Agarwal, Tiyasha De, Jupita Handique et autres

BACKGROUND: Adult-onset recessive cerebellar ataxias comprise a heterogeneous group of disorders. OBJECTIVES: To describe a founder MFSD8 variant in adult-onset cerebellar ataxia. METHODS: We describe three unrelated Indian patients and one sibling pair (n = 5; median age 31 years) who exhibited …

in (code pays fourni par la source)

Diagnostic Yield and Genetic Burden Analysis of Frequently Mutated Genes in Progressive Ataxia

Pooja Sharma, Jupita Handique, Kriti Kashyap, Akhilesh Kumar Sonakar et autres

ABSTRACT: Hereditary ataxias are a group of disorders characterized by clinical manifestations of cerebellar degeneration. Autosomal dominant and recessive forms have been described, and tandem nucleotide repeat expansion are the most prevalent forms of genetic ataxias. In this study, we aimed to …

in (code pays fourni par la source)

Duran And Kleinert Techniques In Flexor Tendon Rehab: A Comparative Analysis

Manisha Pandey, Drishti Pachauri, Bidhan Chandra Bepari, Divya Chadha et autres

Background/Objective- Flexor tendons injuries are one of the most common serious injuries to flexor tendon (flexor digitorum profundus and flexor digitorum superficialis) which are result of lacerations or trauma. The only option of treatment is end to end surgical repair, after which …

in, ae, id (code pays fourni par la source)

Gerstmann-Straussler-Scheinker disease: Lessons from two new Indian kindreds

Farsana Mustafa, Ayush Agarwal, Divyani Garg, Jacky Ganguly et autres

in (code pays fourni par la source)

GRB2 is a BECN1 interacting protein that regulates autophagy

Jetsy Montero-Vergara, Kira Plachetta, Lisa N. Kinch, Stephan Bernhardt et autres

GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation …

de, us, in (code pays fourni par la source)

Unmistakable Truncal Dystonia Mistaken as Psychogenic: A Case Report of VAC14 ‐Related Neurodegeneration

Suvorit Subhas Bhowmick, Shreya Kailashchandra Mahajan, Vishal Shah, Kriti Kashyap

Data S1. In silico analysis of the variants in the VAC14 gene: Figure S1 shows Alpha Fold model of VAC14 with mutated residues; Table S1 shows structural and functional impact of the Ala582Ser and Val669Met variants. Data S2. Excel sheet showing clinicoradiological …

in (code pays fourni par la source)

In silico study of the synergistic anti-tumor effect of hybrid topoisomerase-HDAC inhibitors

Kriti Kashyap, Rita Kakkar

Abstract Combination therapies that include treatment of cancerous cells with histone deacetylase (HDACs) inhibitors prior to treatment with topoisomerase inhibitors have shown synergistic anti-tumor effects. The promising results of such combination therapies have led to the development of a novel class of …

in (code pays fourni par la source)

Pharmacophore-enabled virtual screening, molecular docking and molecular dynamics studies for identification of potent and selective histone deacetylase 8 inhibitors

Kriti Kashyap, Rita Kakkar

in (code pays fourni par la source)

Exploring structural requirements of isoform selective histone deacetylase inhibitors: a comparative in silico study

Kriti Kashyap, Rita Kakkar

Histone deacetylases (HDACs) are a widely popular class of epigenetic regulators, second only in importance to DNA methyltransferases. They are responsible for deacetylating the lysine residues of a wide range of proteins, both nuclear and cytoplasmic. Therefore, deregulated HDAC activity is implicated …

in (code pays fourni par la source)

Exploring structural requirements of isoform selective histone deacetylase inhibitors: a comparative in silico study

Kriti Kashyap, Rita Kakkar

Histone deacetylases (HDACs) are a widely popular class of epigenetic regulators, second only in importance to DNA methyltransferases. They are responsible for deacetylating the lysine residues of a wide range of proteins, both nuclear and cytoplasmic. Therefore, deregulated HDAC activity is implicated …

Synthesis and Reactions of Diazoketones

Ritu Arora, Kriti Kashyap, Anshika Mittal, Rita Kakkar

α-Diazocarbonyl compounds have gained a large amount of attention as they have found many useful applications in organic chemistry. They can be easily prepared, have diverse reactivity, and can be ...

in (code pays fourni par la source)