Joanne Laycock

Radiological outcome of early surgical fixation versus cast immobilization for adults with a scaphoid waist fracture: five-year follow-up of the Scaphoid Waist Internal Fixation for Fractures Trial

Joseph J. Dias, Stephen Brealey, Elizabeth Ann Coleman, Surabhi Choudhary et autres

Aims: In the Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT), surgical fixation was compared with cast immobilization, with the primary endpoint being the outcomes at one year. The aim of the current study was to assess the radiological outcomes (union and …

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Clinical effectiveness of early surgical fixation versus cast immobilization for adults with a scaphoid waist fracture: five-year follow-up of the Scaphoid Waist Internal Fixation for Fractures Trial

Joseph J. Dias, Stephen Brealey, Elizabeth Ann Coleman, Kate Hicks et autres

Aims: In the Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT), surgical fixation was compared with cast immobilization using the Patient-Rated Wrist Evaluation (PRWE) score at one year as the primary endpoint. The aim of this longer-term study was to assess the …

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Effectiveness of polyhexanide, chlorhexidine with neomycin and mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation: non-inferiority RCT (TIDE)

Liz Cook, Sophie James, Joanne Laycock, Ashley Scrimshire et autres

Background The bacterium Staphylococcus aureus is a leading cause of hospital-acquired infections. These infections are difficult to treat when there is increasing resistance to penicillin, known as methicillin-resistant Staphylococcus aureus . Patients who carry Staphylococcus aureus in the nose and skin are …

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Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial

Lydia Flett, Radwa Abdelatif, Sarah Akhtar Baz, Samantha Brady et autres

BACKGROUND: Acute leukaemias (AL) are life-threatening blood cancers that can be potentially cured with treatment involving myelosuppressive, multiagent, intensive chemotherapy (IC). However, such treatment is associated with a risk of serious infection, in particular invasive fungal infection (IFI) associated with prolonged neutropenia. …

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Surgical versus non-surgical management of lateral compression type-1 pelvic fracture in adults 60 years and older: the L1FE RCT

Liz Cook, Joanne Laycock, Dhanupriya Sivapathasuntharam, Camila Maturana et autres

Background Lateral compression type-1 pelvic fractures are a common fragility fracture in older adults. Patients who do not mobilise due to ongoing pain are at greater risk of immobility-related complications. Standard treatment in the United Kingdom is provision of pain relief and …

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The evolution of non-small cell lung cancer metastases in TRACERx

Maise Al Bakir, Ariana Huebner, Carlos Martínez‐Ruiz, Kristiana Grigoriadis et autres

. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, …

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Managing the use of antifungal drugs for blood cancer patients by using blood tests to identify fungal infection

Joanne Laycock, Gavin D Barlow

Abstract 3792: TRACERx: Mapping the evolution of metastases in non-small cell lung cancer

Ariana Huebner, Maise Al Bakir, Kristiana Grigoriadis, Thomas B.K. Watkins et autres

Abstract Background: Primary lung cancer is the leading cause of cancer-related mortality, with metastatic disease being responsible for the majority of deaths. To gain insight into the lethal process of metastasis, we report on the longitudinal evolutionary analysis of the TRACERx 421 …

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A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Yin Wu, Dhruva Biswas, Ieva Usaite, Mihaela Angelova et autres

Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell …

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The Role of Chronic Kidney Disease in Ectopic Calcification

Joanne Laycock, Malgorzata Furmanik, Mengxi Sun, Leon J. Schurgers et autres

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Arterial “inflammaging” drives vascular calcification in children on dialysis

Pilar Sanchís, Chin Yee Ho, Yiwen Liu, Leilani E. Beltran et autres

Children on dialysis have a cardiovascular mortality risk equivalent to older adults in the general population, and rapidly develop medial vascular calcification, an age-associated pathology. We hypothesized that premature vascular ageing contributes to calcification in children with advanced chronic kidney disease (CKD). …

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Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Frederick Arce Vargas, Andrew J.S. Furness, Kevin Litchfield, Kroopa Joshi et autres

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo , increasing the CD8 + to Treg cell ratio and …

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