Akpedje Serena Dossou

Evaluation of the i-Tracker infliximab and i-Tracker anti-infliximab total antibodies ECLIA on the random-access automated analyzer IDS-iSYS for the routine clinical monitoring of infliximab-treated patients

Akpedje Serena Dossou, Tahira Kalhoro, Eduardo Castro Echeverry, Nathan C. Horton

Validation of the i-Tracker Drug and Total Anti-Drug Antibody CLIA Assays on IDS-iSYS for Therapeutic Drug Monitoring in Adalimumab- and Infliximab-Treated Patients

Akpedje Serena Dossou, Tahira Kalhoro, Eduardo Castro-Echeverry, Nathan C. Horton

Background/Objectives: Adalimumab and Infliximab are biologics used to treat autoimmune diseases. Monitoring drug and anti-drug antibody (ADA) levels in patients helps optimize treatment. However, current quantitation methodologies for drug and total (free and drug-bound) ADAs often involve multi-step workflows. Automated systems can …

QUALITY OF LIFE OF CANCER PATIENTS FOLLOWED IN THE MEDICAL ONCOLOGY DEPARTMENT OF A NATIONAL HOSPITAL CENTER OF SENEGAL AND ASSOCIATED FACTORS

André Otti, 2.Beninese Society of Nursing Sciences (SOBESI), Akpedje Serena Dossou, F Seibou. et autres

Introduction: Faced with the highly aversive symptoms and incapacitating side effects of anticancer therapy, the assessment of patients' Quality of Life (QoL) is essential to better inform clinical decisions. Using a mixed design, the QoL of cancer patients followed in the medical …

Phytosynthesis of anisotropic silver and gold nanoparticles: characterization and anticancer activity towards HIO180 and HeyA8 cells

N. L. Gavade, Shamkumar P. Deshmukh, Akpedje Serena Dossou, Sangram Raut et autres

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High-Density Lipoproteins and Cancer, with an Emphasis on Their Role in Immunotherapy

Akpedje Serena Dossou, Nirupama A. Sabnis, Ammar Kapic, Rafał Fudala et autres

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Photophysical Characterization and In Vitro Evaluation of α-Mangostin-Loaded HDL Mimetic Nano-Complex in LN-229 Glioblastoma Spheroid Model

Ammar Kapic, Nirupama A. Sabnis, Akpedje Serena Dossou, Jose L. Chavez et autres

Cytotoxic activity has been reported for the xanthone α-mangostin (AMN) against Glioblastoma multiforme (GBM), an aggressive malignant brain cancer with a poor prognosis. Recognizing that AMN's high degree of hydrophobicity is likely to limit its systemic administration, we formulated AMN using reconstituted …

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A Spontaneous Assembling Lipopeptide Nanoconjugate Transporting the Anthracycline Drug N-Benzyladriamycin-14-valerate for Personalized Therapy of Ewing Sarcoma

Nirupama A. Sabnis, Sangram Raut, Bhavani Nagarajan, Ammar Kapic et autres

To meet the current need for a tumor-selective, targeted therapy regimen associated with reduced toxicity, our laboratory has developed a spontaneously assembled nanostructure that resembles high-density lipoproteins (HDLs). These myristoyl-5A (MYR-5A) nanotransporters are designed to safely transport lipophilic pharmaceuticals, including a novel …

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Phytosynthesis of Anisotropic Silver and Gold Nanoparticles: Characterization and Anticancer Activity Towards Hio180 and Heya8 Cells

N. L. Gavade, Shamkumar P. Deshmukh, Akpedje Serena Dossou, Sangram Raut et autres

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Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells

Akpedje Serena Dossou, Morgan E. Mantsch, Nirupama A. Sabnis, Rance E. Berg et autres

The targeting and conversion of the immunosuppressive (M2) tumor-associated macrophages (TAMs) to an immunostimulatory (M1) phenotype can induce tumor regression in advanced melanoma. We have previously characterized and reported the ability of reconstituted high-density lipoprotein nanoparticles (rHDL NPs) functionalized with DSPE-PEG-mannose (DPM) …

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Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness

Akpedje Serena Dossou, Morgan E. Mantsch, Ammar Kapic, W. L. Burnett et autres

Reconstituted high-density lipoprotein nanoparticles (rHDL NPs) have been utilized as delivery vehicles to a variety of targets, including cancer cells. However, the modification of rHDL NPs for the targeting of the pro-tumoral tumor-associated macrophages (TAMs) remains largely unexplored. The presence of mannose …

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Prospects for developing lipoprotein-based drug transporters for therapeutic applications.

Andras G. Lacko, Nirupama A. Sabnis, Dorota L. Stankowska, Akpedje Serena Dossou et autres

The primary focus of this review is lipoprotein-based drug carriers, more specifically, high-density lipoprotein (HDL) type nanoparticles (NPs). These nanostructures are discussed regarding their suitability for clinical applications, particularly for cancer therapy. Poor solubility and insufficient capability to selectively target malignant tumors …

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High-Density Lipoproteins and Cancer, with an Emphasis on Their Role in Immunotherapy

Akpedje Serena Dossou, Nirupama A. Sabnis, Ammar Kapic, Rafał Fudala et autres

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