Vincent J.J. Odekerken

Intermittent diplopia: a practical guide

Wilco Perini, Veron Verhorst, A van den Berg, Sunjay Parmar et autres

Intermittent binocular diplopia is challenging to assess, as symptoms may be absent during examination yet its possible causes range from benign decompensation to serious disease. We outline a practical method to evaluate intermittent diplopia, focusing on four key steps: (1) confirming binocular …

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Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease

Patricia Zvarova, Christina van der Linden, Ningfei Li, Konstantin Butenko et autres

Abstract Background Accurate electrode placement and individual stimulation parameters influence the outcomes of subthalamic deep brain stimulation in Parkinson’s disease. Neuroimaging-based models can help evaluate how electrode placement impacts improvement, aiming to reduce the burden of DBS programming. However, most existing models …

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Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application

Clemens Neudorfer, Bassam Al‐Fatly, Barbara Hollunder, Ningfei Li et autres

Gene expression shapes the brain's functional connectome, yet it is unclear whether genes linked to the same disorder converge on shared networks. We introduce gene network mapping-a framework combining spatial transcriptomics with normative functional connectivity to identify networks associated with gene expression. …

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Convergent mapping of a tremor treatment network

Lukas L. Goede, Bassam Al‐Fatly, Ningfei Li, Leon Sobesky et autres

Tremor occurs in various forms across diverse neurological disorders, including Parkinson's disease and essential tremor. While clinically heterogeneous, converging evidence suggests a shared brain network may underlie tremor across conditions. Here, we empirically define such a network using four modalities: lesion locations, …

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[ECT in patients with deep brain stimulation: The first cases in the Netherlands].

G J J Mol, Taco Goedemans, Sonja Rutten, Isidoor O. Bergfeld et autres

Electroconvulsive therapy (ECT) is among the most effective treatments for severe depression. However, there is a lack of research regarding its safety and efficacy in patients with deep brain stimulation (DBS). While the available clinical data does not indicate safety concerns, clinicians …

Probabilistic mapping of the antiparkinsonian effects of pallidal deep brain stimulation

Pavel Navratil, Abdullah Elmas, Hazem Eldebakey, Vincent J.J. Odekerken et autres

Abstract Deep brain stimulation of the internal globus pallidus effectively treats motor symptoms and drug-induced fluctuations in advanced Parkinson’s disease—but is complicated by a high variability in outcomes. In a minority of patients, even stimulation-induced aggravation of akinesia has been reported. Previous …

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The correlation between motor improvement and disability in activities of daily living after DBS in Parkinson’s disease, tremor and dystonia

Yarit Wiggerts, Annabel van der Weide, Evan Markidis, Joke M. Dijk et autres

Background Deep brain stimulation (DBS) for Parkinson's disease (PD), essential tremor (ET), and dystonia is a well-established treatment option. The correlation between motor symptom improvement and effect on disability is inconclusive. Objectives To assess the correlation between DBS-induced improvements of motor symptoms …

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Author Correction: Deep brain stimulation of symptom-specific networks in Parkinson’s disease

Nanditha Rajamani, Helen Friedrich, Konstantin Butenko, Till A. Dembek et autres

The original version of this Article contained an error in Figure 2, in which the statistical analyses in the insets of panel B were incorrectly reported. Permutation tests were inadvertently reported instead of circular tests and cross-validation values.

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A New Case Series Suggests That SCA48 (ATX/STUB1) Is Primarily a Monogenic Disorder

Teije van Prooije, Maartje Pennings, Lucille D.A. Dorresteijn, Thatjana Gardeitchik et autres

Abstract Background Monoallelic, pathogenic STUB1 variants cause autosomal dominant cerebellar ataxia (ATX‐ STUB1 /SCA48). Recently, a genetic interaction between STUB1 variants and intermediate or high‐normal CAG/CAA repeats in TBP was suggested, indicating digenic inheritance or a disease‐modifying role for TBP expansions. Objective …

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Deep brain stimulation of symptom-specific networks in Parkinson’s disease

Nanditha Rajamani, Helen Friedrich, Konstantin Butenko, Till A. Dembek et autres

Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson's disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort of patients (N = 237 from five centers) …

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Contributors

Linda Ackermans, Martijn Beudel, I. Daria Bogdan, Maarten Bot et autres

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Deep brain stimulation in rare diseases

Vincent J.J. Odekerken, Martijn Beudel

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