Heikki Oksa

Long-term outcomes of lifestyle intervention to prevent type 2 diabetes in people at high risk in primary health care

Reeta Rintamäki, Nina Rautio, Markku Peltonen, Jari Jokelainen et autres

AIMS: The Finnish National Diabetes Prevention Program (FIN-D2D) was the first large-scale diabetes prevention program in a primary health care setting in the world. The risk reduction of type 2 diabetes was 69% after one-year intervention in high-risk individuals who were able …

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Reedik Mägi, George Dedoussis, Therese Ohlsson, Philippe Frossard et autres

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants …

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Dietary changes and their association with clinical risk factors after diabetes prevention intervention in primary health care

Auli Pölönen, Jaana Lindström, Heikki Oksa, Jari Jokelainen

Incidence of drug-treated type 2 diabetes, cardiovascular events and all-cause mortality according to weight changes of a cohort of people at high risk of diabetes

Reeta Rintamäki, Nina Rautio, Markku Peltonen, Jari Jokelainen et autres

The effect of age and gender on the genetic regulation of serum 25-hydroxyvitamin D - the FIN-D2D population-based study

Maija E. Miettinen, Melissa Smart, Leena Kinnunen, Sirkka Keinänen‐Kiukaanniemi et autres

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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Benjamin M. Neale, Hanna E. Abboud, William R. Scott, Goo Jun et autres

To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic …

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Rare and low-frequency coding variants alter human adult height

Eirini Marouli, Mariaelisa Graff, Carolina Medina‐Gómez, Ken Sin Lo et autres

Abstract Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1–4.8%) and effects of up …

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Praveen Surendran, Fotios Drenos, Robin Young, Helen R. Warren et autres

Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning

Jenni Kulmala, Tiia Ngandu, Satu Pajala, Jenni Lehtisalo et autres

BACKGROUND: Physical activity (PA) has beneficial effects on older age physical functioning, but longitudinal studies with follow-ups extending up to decades are few. We investigated the association between leisure-time PA (LTPA) and occupational PA (OPA) from early to late adulthood in relation …

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Gender differences in thyroid function and obesity among finnish women and men. The FIN-D2D-study

Juha Saltevo, Hannu Kautiainen, Pekka Mäntyselkä, Antti Jula et autres

Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning

Jenni Kulmala, Tiia Ngandu, Satu Pajala, Jenni Lehtisalo et autres

Background:Physical activity (PA) has beneficial effects on older age physical functioning, but longitudinal studies with follow-ups extending up to decades are few. We investigated the association between leisure-time PA (LTPA) and occupational PA (OPA) from early to late adulthood in relation to …

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Changes in glucose metabolism in people with different glucose metabolism disorders at baseline: follow‐up results of a Finnish national diabetes prevention programme

Nina Rautio, Jari Jokelainen, Heikki Oksa, Timo Saaristo et autres

AIM: To examine changes in glucose metabolism (fasting and 2-h glucose) during follow-up in people with impaired fasting glucose in comparison with changes in people with isolated impaired glucose tolerance, people with impaired fasting glucose and impaired glucose tolerance combined and people …

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