Peiyi Xia

CD27 expression is a clinically accessible biomarker for predicting immunotherapy response in melanoma

Peiyi Xia, H. J. Yang, Pu Yu, Yang Miao et autres

Immunotherapy has transformed melanoma treatment, yet only a subset of patients benefit and clinically effective biomarkers remain limited. Here, we report a comprehensive analysis evaluating CD27 as a predictive and prognostic biomarker in melanoma across public datasets and a clinical cohort. Public …

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Mechanistic insights into the T6SS of multi‐drug‐resistant Aeromonas hydrophila and its role in competition and pathogenesis

Ying Liu, Zhao Wang, Peiyi Xia, Zhiwei Li et autres

Abstract Aeromonas hydrophila, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we characterize a multi‐drug‐resistant strain, AH54, which possesses a …

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A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics

Ming Liu, Heng Wang, Zhao Wang, Hao Wang et autres

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BTLA promoter hypomethylation correlates with enhanced immune cell infiltration, favorable prognosis, and immunotherapy response in melanoma

Minglei Yang, Chenxi Zheng, Miao Yu, C. Cameron Yin et autres

Background Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of BTLA promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating its potential …

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Genetic testing and prognosis of sarcomatoid hepatocellular carcinoma patients

Bin Jia, Peiyi Xia, Junqiang Dong, Wenhao Feng et autres

Background Sarcomatoid hepatocellular carcinoma (SHC) is a rare epithelial malignancy with high invasiveness and poor prognosis. However, the molecular characteristics and main driver genes for SHC have not been determined. The aim of this study is to explore the potentially actionable mutations …

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Gefitinib Combined with Cetuximab for the Treatment of Lung Adenocarcinoma Harboring the EGFR–Intergenic Region (SEC61G) Fusion and EGFR Amplification

Guoqing Zhang, Peiyi Xia, Shanshan Zhao, Lulu Yuan et autres

EGFR fusions are rare genomic events in non-small cell lung cancer (NSCLC), and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3, and EGFR-ZCCHC6. EGFR fusion mutations combined with EGFR amplification …

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PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

Yihui Ma, Peiyi Xia, Zhengyang Wang, Jingjing Xu et autres

Protein Disulfide Isomerase Family A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable of catalyzing protein folding and disulfide bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes in various cancers. Herein, gain-of- and …

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Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancers

Peiyi Xia, Lan Zhang, Pan Li, Enjie Liu et autres

BACKGROUND: Complex kinase rearrangement, a mutational process involving one or two chromosomes with clustered rearrangement breakpoints, interferes with the accurate detection of kinase fusions by DNA-based next-generation sequencing (NGS). We investigated the characteristics of complex ALK rearrangements in non-small cell lung cancers …

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Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancers

Peiyi Xia, Lan Zhang, Pan Li, Enjie Liu et autres

Abstract Background Complex kinase rearrangement, a mutational process involving one or two chromosomes with clustered rearrangement breakpoints, interferes with the accurate detection of kinase fusions by DNA-based next-generation sequencing (NGS). We investigated the characteristics of complex ALK rearrangements in non-small cell lung …

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Implication of Microsatellite Instability in Chinese Cohort of Human Cancers

Meiying Cui, Pan Li, Ying Qing Mao, Lan Zhang et autres

BACKGROUND: Microsatellite instability (MSI) has been a hot topic in cancer research. Determining MSI status greatly aids tumor prognosis and treatment plans. However, MSI data for Asian cancer patients with prognostic information are scarce. Here, our aim was to clarify MSI status …

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A Case of Primary Resistance to Gefitinib due to Novel Deletion-Insertion Mutation of EGFR Exon 19 in NSCLC

Peiyi Xia, Enjie Liu, Pan Li, Wencai Li et autres

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Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers

Libo Yang, Feng Ye, Longlong Bao, Xiaoyan Zhou et autres

The correlation of genetic alterations with response to neoadjuvant chemotherapy (NAC) has not been fully revealed. In this study, we enrolled 247 breast cancer patients receiving anthracycline-taxane-based NAC treatment. A next generation sequencing (NGS) panel containing 36 hotspot breast cancer-related genes was …

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