Johana Gutierrez

Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study

Alexy Inciarte, Leire Berrocal, José Ramón Santos, María Remedios Alemán et autres

OBJECTIVES: To assess the prevalence of transmitted drug resistance mutations (TDRMs) and the impact of pre-existing resistance mutations, including minority variants, on virological response in ART-naïve individuals initiating dolutegravir-based triple therapy using next-generation sequencing (GRT-NGS). METHODS: A multicentre, retrospective cohort study was …

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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

Yusuke Isshiki, Xi Chen, Matt Teater, Ioannis Karagiannidis et autres

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Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Abstract Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization of BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show that …

Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Abstract Activated B cell–like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11–BCL10–MALT1 (CBM) signal amplification complexes that form due to polymerization of BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show that …

Supplementary Figure from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Figure from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Figure from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Figure from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

Min Xia, Liron David, Matt Teater, Johana Gutierrez et autres

Supplementary Data from BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL