Feihu Yan

Repurposing rosmarinic acid as an anti-colorectal cancer agent through bolstering T cell anti-tumor immunity by enhancing activation of MEK1-mediated TCR signaling

Zhengchun Kang, Xiaodong Li, Xiuzhu Ma, Feihu Yan et autres

Activation of the T cell receptor (TCR) complex is fundamental to initiating adaptive immune responses, particularly in CD8⁺ cytotoxic T lymphocytes that mediate anti-tumor immunity. However, the immunosuppressive tumor microenvironment often impairs TCR signaling, limiting the efficacy of T cell-based cancer immunotherapies. …

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A highly potent nanobody-based bispecific therapeutic provides broad-spectrum protection against ebolavirus

Meihua Wang, Xinghai Zhang, Wujian Li, Yanfeng Yao et autres

The highly lethal Ebola virus species—Zaire (EBOV), Sudan (SUDV), and Bundibugyo (BDBV)—pose persistent threats to global health. Current antibody therapies target EBOV but lack broad neutralization across ebolaviruses. Recent pan-ebolavirus strategies rely on antibody cocktails. Here, we identified two camelid-derived nanobodies (1A10 …

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基于VSV的苏丹型和本迪布焦型埃博拉病毒致死性替代小鼠模型：用于BSL-2条件下的抗体评价

Baoyue Zhang, Fangxu Li, Fang-Xu Li, Wang Shen et autres

Sudan (SUDV) and Bundibugyo (BDBV) ebolaviruses are major outbreak pathogens lacking approved vaccines or therapeutics. Research progress has been hampered by biosafety level 4 (BSL-4) restrictions. Here, we generated recombinant vesicular stomatitis viruses expressing SUDV or BDBV glycoproteins (VSVΔG-SUDV GP, VSVΔG-BDBV GP) …

Biomimetic nanovaccines with self-adjuvant effects induced broad-spectrum neutralizing antibodies against SARS-CoV-2 infection in rodents

Pengye Du, Yongkun Zhao, Yuan Liang, Cheng Zhang et autres

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants seriously threatens the efficacy of current coronavirus disease 2019 (COVID-19) vaccines. Therefore, there is an urgent need to develop next-generation vaccine platforms capable of counteracting current and prospective viral variants. In this …

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The Functional DPP4 Receptor Is an Indispensable Factor Mediating the Immune Performance of Mucosal Vaccines for Middle East Respiratory Syndrome

Zhenshan Wang, Xiaojun Hu, Shen Wang, Hong-Yu Sun et autres

Mucosal vaccines are powerful tools for combatting emerging infectious diseases, particularly mucosal-associated pathogens. However, one of the main bottlenecks in developing mucosal vaccines is the lack of accurate animal models. In this study, a vesicular stomatitis virus (VSV)-vectored Middle East respiratory syndrome …

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Next‐Generation Vaccines for Co‐Circulating PEDV and TGEV: Integrating Nucleic Acid Platforms, Mucosal Delivery, and AI–Driven Antigen Design

Xiaojun Hu, Zhenshan Wang, Shen Wang, Hongyu Sun et autres

Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are causative agents of acute enteric diseases in pigs and have a high contagion potential. These coronaviruses (CoVs) impose substantial economic losses on global pork production, particularly affecting lactating piglets where coinfections …

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A single dose of an ALVAC vector-based RABV virus-like particle candidate vaccine induces a potent immune response in mice, cats and dogs

Xianyong Meng, Feihu Yan, Weiqi Wang, Shen Wang et autres

Rabies, caused by the Rabies virus (RABV), is a highly fatal zoonotic disease. Existing rabies vaccines have demonstrated good immune efficacy, but the complexity of immunization procedures and high cost has impeded the elimination of RABV, particularly in the post-COVID-19 era. There …

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Trimerized S expressed by modified vaccinia virus Ankara (MVA) confers superior protection against lethal SARS-CoV-2 challenge in mice

Junda Zhu, Zhenshan Wang, Yarui Li, Zihui Zhang et autres

The reoccurrence of successive waves of SARS-CoV-2 variants suggests the exploration of more vaccine alternatives is imperative. Modified vaccinia virus Ankara (MVA) is a virus vector exhibiting excellent safety as well as efficacy for vaccine development. Here, a series of recombinant MVAs …

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Establishment of two serological methods for detecting IgG and neutralizing antibodies against Crimean-Congo hemorrhagic fever virus glycoprotein

Qi Wang, Shen Wang, Zhikang Shi, Zhengrong Li et autres

Introduction: The Crimean-Congo hemorrhagic fever virus (CCHFV), the most geographically widespread tick-borne virus, is endemic in Africa, Eastern Europe and Asia, with infection resulting in mortality in up to 30% of cases. Currently, there are no approved vaccines or effective therapies available …

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Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory

Wanying Yang, Wujian Li, Wujie Zhou, Shen Wang et autres

The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with a case fatality rate of up to 90%. The development of countermeasures against EBOV has been hindered …

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Tandem overexpression of five human factors renders murine hepatocytes susceptible to hepatitis C virus

Liping Lv, Qiong Kang, YU Xiao-yan, Taishan Hu et autres

Development of mouse model of hepatitis C virus (HCV) infection has great significance in drug screening and vaccine research. The barriers of interspecies transmission of HCV are increasingly better understood. Human factors, namely low-density lipoprotein receptor (hLDLR), CD81 (hCD81), scavenger receptor class …

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PP-122 Association between IRF-3 polymorphisms and susceptibility to chronic hepatitis B virus infection

Yanhua Gao, Feihu Yan

Objective: To study the relationship between HBeAg and persistence of HBV infection.Methods: Taking HBeAg negative CHB patients as the research objects, determined the expression of B7-H1/PD-1 and TLR-2 on CD14 + PBMCs and IFN-g and IL-4 in CD3 + CD4 + cells …