Jingyuan Cui

Sulfated chitosan mitigates acute lung injury induced bone loss via immunoregulation

Yongxian Liu, Luli Ji, Fuwei Zhu, Jiaze Yu et autres

Respiratory inflammatory diseases disrupt bone metabolism and cause pathological bone loss. The lung-bone axis is established in chronic diseases like asthma and cystic fibrosis but is less studied in acute lung injury (ALI), recently implicated in COVID-19-induced bone loss. This study examined …

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A Long‐Acting and Sustained‐Release Poly (L‐Lactic Acid) Microsphere System Containing Naringin: Fabrication and In Vitro Bone Modification

Jingyuan Cui, Zhe Zhang, Dong Xu Zhou, Lixin Zhang et autres

ABSTRACT Poly (L‐lactic acid) (PLLA) is a biocompatible and safe polymer, making it an ideal material for fabricating microspheres for drug delivery. In this study, naringin, which a role in bone modification, is used as the active pharmaceutical ingredient, and PLLA is …

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Nervous System-Driven Osseointegration

Ruoyue Sun, Long Bai, Yaru Yang, Yanshu Ding et autres

Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a …

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Differential Nanoscale Topography Dedicates Osteocyte-Manipulated Osteogenesis via Regulation of the TGF-β Signaling Pathway

Jingyuan Cui, Yaru Yang, Peiru Chen, Ruiqiang Hang et autres

Osteocytes function as the master orchestrator of bone remodeling activity in the telophase of osseointegration. However, most contemporary studies focus on the manipulation of osteoblast and/or osteoclast functionality via implant surface engineering, which neglects the pivotal role of osteocytes in de novo …

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The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films

Jiahui Xie, Dawei Jin, Jiaqi Qiu, Jingyuan Cui et autres

O to modulate the association and disassociation between polyphenols and the polymer backbones on demand. DMSO first provides a protective environment to turn off the intermolecular interactions and allows tannic acid (TA) to be dispersed into the polymer network PEG-lysozyme (PEG-LZM) homogeneously. …

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A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

Zhen Geng, Xueping Li, Luli Ji, Zhaoyang Li et autres

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Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics

Yulin Li, Ling Zheng, Lan Xiao, Liudi Wang et autres

MR bimodal imaging functions. Both the in vitro and in vivo results demonstrate that the GO-based nanoplatform displays a good remote photothermal effect, which can damage the dense shell of solid tumor tissue, thereby facilitating the delivery of anticancer drugs into tumor …

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