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Mariah F. Calubag, Ismail Ademi, Cara L. Green, Dulmalika N. H. Manchanayake et autres
Dietary protein is a key regulator of metabolic health in humans and rodents. Many of the benefits of protein restriction are mediated by reduced intake of dietary branched-chain amino acids (leucine, valine and isoleucine) and restriction of the branched-chain amino acids is …
Anna Marie R Schornack, Tyler J. Rodgers, Matthew Shou, Walter Siv et autres
The liver-α cell axis is a finely tuned biological rheostat that regulates whole body amino acid availability. Pancreatic α cells secrete glucagon that regulates amino acid catabolism through gluconeogenesis and ureagenesis, yet the mechanisms linking amino acid levels to α cell growth …
us (code pays fourni par la source)
Erick Spears, Jade E. Stanley, Matthew Shou, Linlin Yin et autres
Interrupting glucagon signaling decreases gluconeogenesis and the fractional extraction of amino acids by liver from blood, resulting in lower glycemia. The resulting hyperaminoacidemia stimulates α cell proliferation and glucagon secretion via a liver/α cell axis. We hypothesized that α cells detect and …
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Kalynn Willis, Charles Opara, Brian S. Yandell, Chris Emfinger et autres
The AttieLab-QTL-Viewer is a modular R/Shiny web application for exploring quantitative trait loci in Diversity Outbred mouse data. It provides access to genome-wide RNA expression data from the livers of 1200 DO samples, as reported in Opara et al. (See preprint information). …
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Kalynn Willis, Charles Opara, Kelly A. Mitok, Chris Emfinger et autres
The AttieLab-QTL-Viewer is a modular R/Shiny web application for exploring quantitative trait loci in Diversity Outbred mouse data. It provides access to genome-wide RNA expression data from the livers of 1200 DO samples, as reported in Opara et al. (See preprint information). …
us (code pays fourni par la source)
Sisi Lai, Mark P. Keller, Jinglin Zhang, Zhou Fang et autres
Altered proinsulin levels in β-cells and bloodstream are hallmarks of diabetes and other diseases, but our knowledge about the proinsulin regulators remains limited. Here we perform a genome-wide CRISPR screen to identify 84 proinsulin regulators that alter intracellular proinsulin/insulin ratio in a …
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Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le et autres
Dietary protein regulates metabolic health and aging, with many benefits of a low protein diet resulting from reduced consumption of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and valine. Each BCAA has distinct physiological and molecular effects, and while restriction of …
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C. Opara, Kelly A. Mitok, Christopher H. Emfinger, Katheryn L Schueler et autres
Abstract Genetic association studies of mRNA abundance phenotypes link regulatory gene loci to mRNA abundance (quantitative trait loci; QTL). Here, we used liver RNA-seq data from a large cohort of the Diversity Outbred (DO) mouse population to map QTL for gene abundance …
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Brynn E. LeMasters, Caitlyn R. Fields, Justin P. Lomont, Farzaneh Chalyavi et autres
S. Using two-dimensional infrared spectroscopy, we monitor the structure of IAPP from seven different mammals, five of which are from species that can develop type 2 diabetes (ferret, raccoon, cat, baboon, and human) and three from those that do not (hamster, rat, …
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Shivani T. Shivani, Brynn E. LeMasters, Thirupathi Ravula, Harrison J. Esterly et autres
Amyloid oligomers of the human islet amyloid polypeptide (hIAPP) are a likely cytotoxic species driving β-cell death in type 2 diabetes, but their transient nature has precluded atomic-level structural characterization. We obtained a high-resolution structure of a physiologically relevant hIAPP oligomer. Using …
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Candice N. Baker, Jeffrey M. Harder, Daniel A. Skelly, Isabela Gerdes Gyuricza et autres
Summary Model organisms have provided critical insights into the basic biology of metabolic disorders, however, one of the greatest limitations to translation has been the absence of the genetic heterogeneity that is characteristic of human populations. We examined metabolic health across three …
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Candice N. Baker, Jeffrey M. Harder, Daniel A. Skelly, Isabela Gerdes Gyuricza et autres
Summary Model organisms have provided critical insights into the basic biology of metabolic disorders, however, one of the greatest limitations to translation has been the absence of the genetic heterogeneity that is characteristic of human populations. We examined metabolic health across three …
us, gb (code pays fourni par la source)
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