Anmol Saini

GM-CSF increases glucose uptake and mitochondrial activity and reduces reactive oxygen species levels in mouse cumulus-oocyte complexes during oocyte in vitro maturation

Anmol Saini, Hannah E. Lyons, Nicole O. McPherson, Mark B. Nottle

We have previously reported that the addition of granulocyte macrophage-colony stimulating factor (GM-CSF) during oocyte in vitro maturation (IVM) can increase embryo development in mice. The present study examined glucose uptake, mitochondrial activity, reactive oxygen species (ROS) levels, and the expression of …

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THE ADDITION OF GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR DURING IN VITRO OOCYTE MATURATION IMPROVES MITOCHONDRIAL ACTIVITY AND REDUCES ROS LEVELS

Anmol Saini, Nicole O. McPherson, Mark B. Nottle

Determination of an Optimal Concentration of GM-CSF for Improving Oocyte in vitro Maturation in a Mouse Model

Anmol Saini, Nicole O. McPherson, Mark B. Nottle

Background: We have previously reported the addition of 10[Formula: see text]ng/mL of granulocyte-macrophage colony-stimulating factor (GM-CSF) during in vitro maturation (IVM) increases embryo development in a mouse model of IVM. The present study determined whether 5[Formula: see text]ng/mL of GM-CSF is a …

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GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR DURING IN VITRO OOCYTE MATURATION IMPROVES IMPLANTATION AND FETAL NUMBERS

Anmol Saini, Nicole O. McPherson, Mark B. Nottle

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Addition of GM-CSF during in vitro oocyte maturation improves embryo development and implantation and birth rate in mice

Anmol Saini, Nicole O. McPherson, Mark B. Nottle

The present study determined whether adding granulocyte–macrophage colony-stimulating factor (GM-CSF) during in vitro oocyte maturation (IVM) could improve oocyte developmental competence by examining embryo development and implantation and birth rates following embryo transfer in mice. In an initial dose-response experiment, we demonstrated …

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Addition of granulocyte macrophage colony stimulating factor (GM-CSF) during in vitro oocyte maturation improves embryo development in a mouse model of advanced maternal age

Anmol Saini, Nicole O. McPherson, Mark B. Nottle

Oocyte developmental competence declines in women aged 35 and older resulting in many women resorting to IVF. The present study determined whether adding Granulocyte-macrophage colony-stimulating factor (GM-CSF) during in vitro oocyte maturation (IVM) could improve oocyte developmental competence in a mouse model …

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#239 : Granulocyte-Macrophage-Colony Stimulating Factor Improve Embryo Development, Mitochondrial Function and Spindle Alignment in a Mouse Model of Advanced Maternal Age

Anmol Saini, Nicole O. McPherson, Johan Smitz, Mark B. Nottle

Background and Aims: We have previously shown that GM-CSF can improve embryo development when added during in vitro oocyte maturation (IVM) as well as increase pregnancy and birth rates following embryo transfer in mice. The aim of the present study was to …

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Clinical use of progesterone in human sperm preparation media for increasing IVF success

Nicole O. McPherson, Mark B. Nottle, Anmol Saini, Hamish Hamilton et autres

RESEARCH QUESTION: Can the addition of progesterone and neurotensin, molecular agents found in the female reproductive tract, after sperm washing increase the fertilization potential of human spermatozoa? DESIGN: (i) Cohort study of 24 men. Spermatozoa selected by swim-up were incubated in either …

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Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

Andrew Peel, Anmol Saini, Joshua C. Deluao, Nicole O. McPherson

Obesity prevalence worldwide is increasing significantly. Whilst maternal obesity has clear detrimental impacts on fertility, pregnancy and foetal outcomes, more recently there has been an increasing focus on the role of paternal obesity in human fertility. Recent meta-analyses have indicated that obesity …

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