Giulia Damiano

Messenger RNA (mRNA) based therapeutics in transforming cardiovascular care: Progress, regulatory challenges and future perspectives

Mudassir Khan, Umberto M. Musazzi, Sara Manellari, Nayla Mouawad et autres

Messenger RNA (mRNA) based therapeutics in transforming cardiovascular care: Progress, regulatory challenges and future perspectives

Mudassir Khan, Umberto M. Musazzi, Sara Manellari, Nayla Mouawad et autres

Messenger RNA (mRNA) is emerging as a new tool for therapeutic intervention, providing a transient, programmable platform for the treatment of complex diseases. Unlike DNA-based therapies, mRNA does not integrate into the genome and is considered more safe. The success of mRNA …

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Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies

Giulia Damiano, Raffaella Rinaldi, Angela Raucci, Chiara Molinari et autres

The pathophysiological mechanisms of cardiovascular disease and microvascular complications in diabetes have been extensively studied, but effective methods of prevention and treatment are still lacking. In recent years, DNA methylation, histone modifications, and non-coding RNAs have arisen as possible mechanisms involved in …

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Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Maria Cristina Vinci, Sarah Costantino, Giulia Damiano, Erica Rurali et autres

Abstract Background Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activation and inflammation are initiated in hematopoietic stem/progenitor cells (HSPCs) and transferred to differentiated …

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Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Maria Cristina Vinci, Sarah Costantino, Giulia Damiano, Erica Rurali et autres

Abstract Background: Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activation and inflammation are initiated in hematopoietic stem/progenitor cells (HSPCs) and transferred to differentiated …

it, ch, au (code pays fourni par la source)

The Long Telling Story of “Endothelial Progenitor Cells”: Where Are We at Now?

Maria Cristina Vinci, Ermes Carulli, Erica Rurali, Raffaella Rinaldi et autres

Endothelial progenitor cells (EPCs): The name embodies years of research and clinical expectations, but where are we now? Do these cells really represent the El Dorado of regenerative medicine? Here, past and recent literature about this eclectic, still unknown and therefore fascinating …

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