Julie Dawson

The diagnosis and management of systemic autoimmune rheumatic disease-related interstitial lung disease: British Society for Rheumatology guideline scope

Jennifer R. Hannah, Mia Rodziewicz, Puja Mehta, Kerri-Marie Heenan et autres

Interstitial lung disease (ILD) is a significant complication of many systemic autoimmune rheumatic diseases (SARDs), although the clinical presentation, severity and outlook may vary widely between individuals. Despite the prevalence, there are no specific guidelines addressing the issue of screening, diagnosis and …

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The influence of deprivation in the outcomes of psoriatic arthritis within the UK—utilizing Outcomes of Treatment in Psoriatic Arthritis Study Syndicate (OUTPASS) data

Max Lyon, Sizheng Steven Zhao, Meghna Jani, Hector Chinoy et autres

Max Lyon, Sizheng Steven Zhao, Megna Jani, Hector Chinoy, Anne Barton, James Bluett, OUTPASS study syndicate; The influence of deprivation in the outcomes

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Non-trough serum drug levels of adalimumab and etanercept are associated with response in patients with psoriatic arthritis

Philippa D. K. Curry, Ryan Malcolm Hum, Andrew Paul Morris, Meghna Jani et autres

OBJECTIVES: Up to 40% of psoriatic arthritis (PsA) patients experience first-line Tumour Necrosis Factor inhibitors (TNF-i) failure. Lower serum drug levels (SDL) have been associated with lower response in autoimmune conditions. This study aimed to: (i) establish the relationship between adalimumab (ADL) …

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Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response

Philippa D. K. Curry, Andrew Paul Morris, Meghna Jani, Hector Chinoy et autres

Abstract Objective The aim of this study was to assess the relationship between self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD (csDMARD) co-therapy in TNF inhibitor (TNF-i) drug response in PsA. Methods Serum samples and adherence questionnaires were collected at …

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Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

Joshua J. Solomon, Sonye Karen Danoff, Felix Woodhead, Shelley Hurwitz et autres

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Does methotrexate cause progressive fibrotic interstitial lung disease? A systematic review

Julie Dawson, Edmond Quah, Ben A M Earnshaw, Constanta Amoasii et autres

The aim is to evaluate the published evidence on whether methotrexate (MTX) use causes progressive fibrotic interstitial lung disease (fILD). This PRISMA-compliant systematic review has been registered electronically with PROSPERO 2018 ID CRD42018087838, Centre of review and dissemination at the University of …

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Rheumatoid arthritis related interstitial lung disease – improving outcomes over 25 years: a large multicentre UK study

Clive Anthony Kelly, Mohamed Nisar, Suba Arthanari, Sarah Carty et autres

OBJECTIVE: This study explores whether the prognosis of interstitial lung disease in rheumatoid arthritis (RA-ILD) has improved over time and assesses the potential influence of drug therapy in a large multicentre UK network. METHODS: We analysed data from 18 UK centres on …

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THU0542 THE IMPACT OF GLUCOCORTICOID INITIATION ON THE DIAGNOSTIC ACCURACY OF ULTRASOUND IN GIANT CELL ARTERITIS: EXPERIENCES FROM A DISTRICT GENERAL HOSPITAL IN THE UK

Jeeu Teck Sze, Julie Dawson

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Systematic literature review investigating whether methotrexate causes chronic pulmonary fibrosis

Ed Quah, Constanta Amoasii, Tareg Mudawi, Julie Dawson

With regards the articles in the rejecting group, they are higher scoring on the Downs and Black score and have only low-tomoderate risk of bias.They contain cohort studies, one review article and two meta-analyses of randomised controlled trials of methotrexate.The study populations …

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Systematic literature review investigating whether methotrexate causes chronic pulmonary fibrosis

Ed Quah, Constanta Amoasii, Tareg Mudawi, Julie Dawson

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P154 Systematic literature review investigating whether methotrexate causes chronic interstitial pulmonary fibrosis

Ed Quah, Ben A M Earnshaw, Julie Dawson

Background Methotrexate is a treatment widely used in many medical conditions. Methotrexate is associated with a potentially fatal methotrexate pneumonitis. The aim of this study is to undertake a systematic literature review to evaluate the published evidence on whether methotrexate causes a …

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246 No evidence that pulmonary fibrosis is a complication of long term methotrexate use: 10 year follow up data of patients treated with methotrexate for inflammatory arthritis

Julie Dawson, Ben A M Earnshaw, Imna Rahiman, Deepti Kapur

Background: Methotrexate (MTX) use is known to be associated with acute pneumonitis, an acute hypersensitivity reaction, with a prevalence currently ranging from 0.5 -1%. Some clinicians have concerns that methotrexate use can also cause direct lung toxicity leading to pulmonary fibrosis. The …

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