Philip Britz‐McKibbin

Prognostic biomarkers of future diabetes in South Asian women diagnosed with gestational diabetes: a prospective cohort study

Sandi M. Azab, Amel Lamri, Anastasia Gayowsky, Meera Shanmuganathan et autres

BACKGROUND: Gestational diabetes (GDM) confers an increased risk of future type-2 diabetes (T2D). We aimed to identify determinants of the progression of GDM to T2D in South Asian women and develop a precision prognostics model for potential future clinical application. METHODS: This …

ca, Égypte (code pays fourni par la source)

Preksha Dhyana meditation modulates the serum metabolome in healthy and meditation-naïve participants

Bassam Abomoelak, Nidhi Kapoor, Mary Schreck, Samani U. Pragya et autres

The impact of various meditation interventions on modifying human health outcomes has been demonstrated at both cognitive and cellular levels. Preksha Dhyana (PD) meditation has previously shown effects on cognitive skills, transcriptome, and the DNA methylome in healthy, novice college students. In …

us, ir, ru, ca (code pays fourni par la source)

29 SNAT2 AS A NOVEL TARGETABLE VULNERABILITY IN RECURRENT GLIOBLASTOMA

Anish Puri, José Carlos Bozelli, William Maich, Dillon McKenna et autres

Abstract Glioblastoma (GBM) is the most fatal primary brain tumour. Standard-of-care consists of surgical resection followed by chemo-radiotherapy, but the tumour almost always recurs. There are currently no effective treatments at recurrence, and this contributes to why patients with GBM have a …

ca (code pays fourni par la source)

Serum Metabolome As Indicators of Growth Failure From Children of 6–59 Months: Results From the Brazilian National Survey on Child Nutrition (ENANI-2019)

Gilberto Kac, Samary da Silva Rosa Freire, Victor N. Keller, Raquel Machado Schincaglia et autres

br, ca (code pays fourni par la source)

Corrigendum to “Treatment response variations to a single large bolus of enteral cholecalciferol in vitamin D deficient critically ill children: Metabolomic insights for precision nutrition” [J. Steroid Biochem. Mol. Biol. 250 (2025) 106720]

Erick Helmeczi, Katie O’Hearn, Dayre McNally, Philip Britz‐McKibbin

ca (code pays fourni par la source)

Treatment response variations to a single large bolus of enteral cholecalciferol in vitamin D deficient critically Ill children: Metabolomic insights for precision nutrition

Erick Helmeczi, Katie O’Hearn, Dayre McNally, Philip Britz‐McKibbin

Vitamin D deficiency (VDD) is prevalent globally and in pediatric intensive care units, where it represents a modifiable risk factor that may impact patient recovery during hospitalization. Herein, we performed a retrospective analysis of serum samples from a phase-II randomized placebo-controlled trial …

ca (code pays fourni par la source)

Environmental Exposures and Health Risks: A Metabolomics Perspective on Exposomics Research

Ana Ruxandra Stanciu, Philip Britz‐McKibbin

Exposomics refers to the comprehensive analysis of environmental exposures over the lifespan and assessment of their biological effects on human health. This new frontier in environmental research promises new insights for assessment of the hazards of complex chemical exposures as compared to …

ca (code pays fourni par la source)

Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

Marina Padilha, Victor N. Keller, Paula Normando, Raquel Machado Schincaglia et autres

Background: The role of circulating metabolites on child development is understudied. We investigated associations between children’s serum metabolome and early childhood development (ECD). Methods: Untargeted metabolomics was performed on serum samples of 5004 children aged 6–59 months, a subset of participants from …

br, ca (code pays fourni par la source)

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype signaling

Michael Kamal, Meera Shanmuganathan, Zachary Kroezen, Sophie Joanisse et autres

Cellular senescence and its accompanying secretory phenotype [i.e., the senescence-associated secretory phenotype (SASP)] have been linked to the aging-associated dysfunction of skeletal muscle, yet little is known about this phenomenon in satellite cells. We report that senescent myoblasts experience a significantly altered …

ca, gb (code pays fourni par la source)

A Software Tool for Rapid and Automated Preprocessing of Large-Scale Serum Metabolomic Data by Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Erick Helmeczi, Zachary Kroezen, Meera Shanmuganathan, Ana Ruxandra Stanciu et autres

Mass spectrometry (MS)-based metabolomics often rely on separation techniques when analyzing complex biological specimens to improve method resolution, metabolome coverage, quantitative performance, and/or unknown identification. However, low sample throughput and complicated data preprocessing procedures remain major barriers to affordable metabolomic studies that …

ca, br, rs (code pays fourni par la source)

The role of urine metabolomics in the diagnosis and management of adult and pediatric Crohn’s disease and ulcerative colitis

Kanish Baskaran, Michal Moshkovich, Lara Hart, Nyah Shah et autres

INTRODUCTION: Urine metabolomics offers a non-invasive approach to diagnose and manage inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), by identifying distinct metabolic signatures. OBJECTIVES: This narrative review summarizes current findings on urinary metabolites in IBD, evaluating their …

ca, us (code pays fourni par la source)

Potential Risks from Cannabis- Infused Beverages: A Critical Review

Anna M. Froude, Nikki Pangborn, Philip Britz‐McKibbin, James MacKillop et autres

Although Canada legalized cannabis beverages in 2019, most available research on acute cannabis intoxication derives from dried flower and edible products. The distinct bioavailability and pharmacokinetic properties of phytocannabinoids ingested from beverages, however, contribute to significantly different acute and long-term effects that …

ca (code pays fourni par la source)