R. Attard

the high-impact use case of atherosclerotic cardiovascular disease

Stephanie Bezzina Wettinger, Kanita Karađuzović-Hadžiabdić, R. Attard, Rosienne C. Farrugia et autres

Despite striking successes in identifying novel biomarkers for improved patient stratification and predicting disease progression, numerous challenges remain in the effective integration and exploitation of multiomic data in biomedical applications beyond cancer, for which most bioinformatics strategies are developed and validated. That …

Bottlenecks in advancing and applying multiomic data integration—common data resources as rate-limiting drivers—the high-impact use case of atherosclerotic cardiovascular disease

Stephanie Bezzina Wettinger, Kanita Karađuzović-Hadžiabdić, R. Attard, Rosienne C. Farrugia et autres

Despite striking successes in identifying novel biomarkers for improved patient stratification and predicting disease progression, numerous challenges remain in the effective integration and exploitation of multiomic data in biomedical applications beyond cancer, for which most bioinformatics strategies are developed and validated. That …

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Isolating high-quality RNA for RNA-Seq from 10-year-old blood samples

C Portelli, Elisa Seria, R. Attard, Mitra Barzine et autres

There is much interest in analysing RNA, particularly with RNA Sequencing, across both research and diagnostic domains. However, its inherent instability renders it susceptible to degradation. Given the imperative for RNA integrity in such applications, proper storage and biobanking of blood samples …

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High Population Frequency of GNRHR p.Q106R in Malta: An Evaluation of Fertility and Hormone Profiles in Heterozygotes

Clayton John Axiak, Adrian Pleven, R. Attard, Francesca Borg Carbott et autres

Abstract Context The gonadotropin-releasing hormone receptor variant GNRHR p.Q106R (rs104893836) in homozygosity, compound heterozygosity, or single heterozygosity is often reported as the causative variant in idiopathic hypogonadotropic hypogonadism (IHH) patients with GnRH deficiency. Genotyping of a Maltese newborn cord-blood collection yielded a …

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Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA17129

Maarten Vanhaverbeke, R. Attard, Monika Barteková, Soumaya Ben‐Aicha et autres

Despite significant advances in the diagnosis and treatment of cardiovascular diseases, recent calls have emphasized the unmet need to improve precision-based approaches in cardiovascular disease. Although some studies provide preliminary evidence of the diagnostic and prognostic potential of circulating coding and non-coding …

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Smoking- and alcohol consumption-induced changes in mrna levels of inflammation-related molecules.

R. Attard, Philip Francis Dingli, A.C. Spek, Kevin Cassar et autres

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The impact of metabolic factors on inflammatory mrna expression profiles: Findings from the MAMI study

R. Attard, Philip Francis Dingli, A.C. Spek, Kevin Cassar et autres

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Idiopathic hypogonadotropic hypogonadism in the Maltese island population : a spectrum of phenotypes and genotypes

C. Axiak, Adrian Pleven, Francesca Borg Carbott, R. Attard et autres

Idiopathic Hypogonadotropic Hypogonadism (IHH) is a rare, genetically heterogeneous infertility disorder characterized by absent or incomplete sexual maturation by age 18. This is due to a deficiency or absence of either pulsatile hypothalamic secretion of gonadotropin-releasing hormone (GnRH) and/or gonadotropins from the …

The impact of frequency, pattern, intensity, and type of alcohol consumption, and its combined effect with smoking on inflammation, lipid profile, and the risk of myocardial infarction

R. Attard, Philip Francis Dingli, Carine J.M. Doggen, Karen Cassar et autres

Abstract Aim To determine the risk of myocardial infarction (MI) associated with pattern, frequency, and intensity of alcohol consumption, type of alcoholic beverage, and the combined effect of alcohol and smoking on risk of MI, inflammation, and lipid profile. Method A total …

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Effect of the macrophage migration inhibitory factor genotype on risk of myocardial infarction is modulated by other risk factors

R. Attard, Philip Francis Dingli, Catharina Jacoba Maria Doggen, Kevin Cassar et autres

The independent effect of helicobacter pylori infection and elevated gastrin levels on the risk of myocardial infarction

R. Attard, Philip Francis Dingli, Carine J.M. Doggen, Karen Cassar et autres

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The impact of passive and active smoking on inflammation, lipid profile and the risk of myocardial infarction

R. Attard, Philip Francis Dingli, Carine J.M. Doggen, Karen Cassar et autres

OBJECTIVE: To investigate the effect of passive smoking, active smoking and smoking cessation on inflammation, lipid profile and the risk of myocardial infarction (MI). METHODS: A total of 423 cases with a first MI and 465 population controls from the Maltese Acute …

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