Leonie van der Zee

LDL RECEPTOR-MEDIATED UPTAKE OF LIPOPROTEINS FUELS HUMAN CD4+ T CELL POLARIZATION TOWARDS A C-MAF-IL-10 AND FOXP3-DRIVEN REGULATORY PHENOTYPE

Angela Markovska, Niels S. van Heusden, Enric Mocholí, Edwin C.A. Stigter et autres

LDL receptor–mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10– and FOXP3-driven phenotype

Angela Markovska, Niels S. van Heusden, Dagmar Duijzer, Alejandra Bodelón et autres

Human CD4+ T cells utilize nutrients, including lipids, to support their activation and polarization. Considering the pivotal role of lipoproteins in lipid transport, we reasoned that lipoprotein uptake and processing could effect CD4+ T cell function. Here, we demonstrate that activation of …

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Lipoprotein(a), atherosclerotic plaque burden, and long-term cardiovascular outcomes in patients with coronary artery disease

Jose V F de Mira, Selina Vlieger, Monique Mulder, Leonie van der Zee et autres

BACKGROUND & AIMS: Although lipoprotein(a) [Lp(a)] is an established independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in primary prevention settings, it remains unclear whether Lp(a) contributes to an increased risk of adverse cardiovascular events in patients with established ASCVD. METHODS: The …

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Relation of Lp(a) with plaque characteristics and clinical events: ATHEROREMO and IBIS_3 cohorts

J M Veiga-Fernandes Mira, Selina Vlieger, M Mulder, Leonie van der Zee et autres

Abstract Background & aims Although lipoprotein(a) [Lp(a)] is an established independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in primary prevention settings, it remains unclear whether Lp(a) contributes to an increased risk of adverse cardiovascular events in patients with established ASCVD. Objective …

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Morphology control of volatile resistive switching in La0.67Sr0.33MnO3 thin films on LaAlO3 (001)

Azminul Jaman, Anouk S. Goossens, Job J. L. van Rijn, Leonie van der Zee et autres

The development of in-memory computing hardware components based on different types of resistive materials is an active research area. These materials usually exhibit analog memory states originating from a wide range of physical mechanisms and offer rich prospects for their integration in …

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ENVIRONMENTAL FACTORS INFLUENCING SYMPTOMS AND USE OF RELIEF MEDICATIONS IN SUBJECTS WITH SEASONAL ALLERGIC RHINOCONJUNCTIVITIS

T. Zwingers, K. Oluwayi, Leonie van der Zee, Ollie Armfield et autres

STATINS, BUT NOT PCSK9 INHIBITORS, REDUCE THE ADIPOKINE CHEMERIN IN FAMILIAL HYPERCHOLESTEROLEMIA: FOCUS ON LIPOPROTEIN SUBFRACTIONS

Lunbo Tan, Na Wang, Leonie van der Zee, Jeanine E. Roeters van Lennep et autres

Objective: Familial hypercholesterolemia (FH) is characterized by severe elevations in circulating LDL-cholesterol, and an increase in the risk of dyslipidemia-related cardiovascular disease (CVD). Chemerin, as a newly identified adipokine, is considered as an additional risk factor for CVD. Here we investigated whether …

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Comprehensive (apo)lipoprotein profiling in patients with genetic hypertriglyceridemia using LC-MS and NMR spectroscopy

Maaike E. Straat, Borja Martínez‐Téllez, Kimberly J. Nahon, Laura G.M. Janssen et autres

BACKGROUND: Mutations in genes encoding lipoprotein lipase (LPL) or its regulators can cause severe hypertriglyceridemia (HTG). Thus far, the effect of genetic HTG on the lipid profile has been mainly determined via conventional techniques. OBJECTIVE: To show detailed differences in the (apo)lipoprotein …

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HDL associates with insulin resistance and beta-cell dysfunction in South Asian families at risk of type 2 diabetes

Reyhane Yahya, Sjaam Jainandunsing, Mardin Rashid, Leonie van der Zee et autres

Dyslipidemia precedes type 2 diabetes (T2D) and worsens with increasing glucose intolerance. First degree relatives of T2D patients have an increased risk to develop dyslipidemia and glucose intolerance. The aim of the present study was to assess the relation between the development …

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Jeuk

Leonie van der Zee, Hok Bing Thio

Jeuk is een veelvoorkomende klacht, die meestal veroorzaakt wordt door een huidziekte. Gegeneraliseerde jeuk zonder huidafwijkingen, pruritus sine materia, wordt vooral gezien bij ouderen. Meestal is dan een droge huid, xerosis senilis, de …

How significant is the antifibrinolytic effect of lipoprotein(a) for blood clot lysis?

Dingeman C. Rijken, Judith J. de Vries, Joyce J. M. C. Malfliet, Sven Bos et autres

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Food intake improves anti-inflammatory function of HDL from patients with type 2 diabetes

Monique T. Mulder, Roosmarijn F.H. Lemmers, Nikita Martens, Leonie van der Zee et autres

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