Alastair Brown

Furosemide with adjunctive acetazolamide vs furosemide only in critically ill patients: A pilot two-center randomized controlled trial

Akinori Maeda, Alastair Brown, Sofia Spano, Anis Chaba et autres

PURPOSE: Furosemide is the most commonly used diuretic in intensive care units (ICU). We aimed to evaluate the physiological effects of adjunctive acetazolamide with furosemide on diuresis and the prevention of potential furosemide-induced metabolic alkalosis. MATERIALS AND METHODS: We performed a two-center, …

au, jp, br (code pays fourni par la source)

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

gb (code pays fourni par la source)

A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study

Rahul Costa‐Pinto, Zhen-Ti Yong, Fumitaka Yanase, Chelsea Young et autres

au, nz (code pays fourni par la source)

Nature and impact of in-hospital complications associated with persistent critical illness

Boris Tseitkin, Johan Mårtensson, Glenn M. Eastwood, Alastair Brown et autres

Persistent critical illness (PerCI) is a relatively novel term to describe a clinical syndrome.1 This term applies to a heterogeneous group of patients who receive prolonged intensive care unit (ICU) support and have been previously arbitrarily referred to as having "chronic" or …

au, se, it, jp, us (code pays fourni par la source)

A pilot randomised controlled trial evaluating the pharmacodynamic effects of furosemide versus acetazolamide in critically ill patients

Alastair Brown, Salvatore Lucio Cutuli, Glenn M. Eastwood, Laurent Bitker et autres

Objective: To compare the physiological and biochemical effects of a single intravenous dose of furosemide or acetazolamide in critically ill patients. Design: Single centre, pilot randomised controlled trial. Setting: Large tertiary adult intensive care unit (ICU). Participants: Twenty-six adult ICU patients deemed …

au, gb, it, ro, fr (code pays fourni par la source)