Xin Ming M Zhou

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M Zhou et autres

BACKGROUND & AIMS: Primary liver cancer is the third leading cause of cancer death worldwide, and about 70% of hepatocellular carcinomas (HCCs) do not respond to systemic immunotherapies. Transarterial chemoembolization (TACE) remains standard treatment for intermediate-stage HCC, but long-term survival is poor. …

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PD-L1–Negative Macrophages Are Associated with Poor Outcomes and High-Grade Immune-Related Adverse Event Development in Patients with Melanoma Receiving Anti–PD-1 Immunotherapy

Xin Ming M Zhou, Kaitlin L. Williams, Elizabeth Will, Daniel Jiménez‐Sánchez et autres

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Spatial proteomics for investigating solid tumor resistance mechanisms

Xin Ming M Zhou, Anjali D'Amiano, Charles Lu, Vrinda Madan et autres

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DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

Sachin S. Surwase, Xin Ming M Zhou, Kathryn M Luly, Qingfeng Zhu et autres

Presented here is an emerging DNA-barcode-based multiplex imaging technique based on Co-Detection-by-indEXing that analyzes the spatial proteomics of tissue microenvironments. Successful imaging requires a repertoire of well-designed and properly validated antibody panels, but very few currently exist for formalin-fixed paraffin-embedded (FFPE) samples. …

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26 High-plex immunofluorescence imaging yields insights into antigen presentation and checkpoint expression following nanoparticle reprogramming of murine melanoma

Xin Ming M Zhou, Sachin S. Surwase, Kathryn M Luly, Jordan J. Green et autres

Background We have previously shown that 4-1BBL/IL-12 nanoparticles (NPs) are capable of eliciting potent immune responses in B16F10 melanoma tumors.1 We further showed that incorporation of IFNγ plasmid drove higher levels of MHC-I expression in vitro compared to 4-1BBL/IL-12 or control Nps.2 …

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1410 Novel high-plex CODEX panel reveals induced immune changes from signal 2/3 gene delivery to murine melanoma

Sachin S. Surwase, Xin Ming M Zhou, Kathryn M Luly, Jordan J. Green et autres

Background CODEX is an emerging high-plex technique that allows the visualization of protein biomarkers while maintaining tissue architecture. Few antibodies are available to study murine formalin-fixed paraffin-embedded (FFPE) tissues, which offer several advantages over fresh-frozen tissue with respect to ease of handling/storage …

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Highly Multiplexed Immunofluorescence PhenoCycler Panel for Murine Formalin-Fixed Paraffin-Embedded Tissues Yields Insight Into Tumor Microenvironment Immunoengineering

Sachin S. Surwase, Xin Ming M Zhou, Kathryn M Luly, Qingfeng Zhu et autres

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Curving out a new path: CD28/B7 cis interactions

Xin Ming M Zhou, Alexander M. Mørch, Michael L. Dustin

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Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review

Justin Matheson, Xin Ming M Zhou, Zoe Bourgault, Bernard Le Foll

The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption. Obesity has been associated with higher levels of the endogenous cannabinoid transmitters (endocannabinoids). Therefore, the ECS is an important target in …

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