Jichen Sha

High-Glucose Microenvironment Promotes Canine Osteosarcoma Cell Stemness via the HBP/O-GlcNAc Signaling Axis

Weiqian Wang, Bingsong Yang, Guangmin Zhang, Meimei Wang et autres

Osteosarcoma (OS) is characterized by high metastatic potential and marked chemoresistance, with cancer stem cells (CSCs) serving as major drivers of malignant progression. Canine osteosarcoma (cOS) is considered an ideal comparative medicine model for human osteosarcoma (hOS). Accumulating evidence indicates that aberrant …

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Abstract 4419: Development of a first-in-class camptothecin-based antibody-drug conjugate targeting ALPP/ALPPL2 with potent antitumor activity and excellent tolerability

Rui Liu, Lingli Zhang, Fan Yang, Junjie Zhang et autres

Abstract Introduction: ALPP (alkaline phosphatase, placental) and ALPPL2 (alkaline phosphatase, placental-like 2) emerge as promising targets due to their expression across multiple solid tumors, including ovarian (60%), endometrial (50%), pancreatic (30%), and gastric cancer (15%) along with minimal expression in normal adult …

Chlorogenic Acid Alleviates Chronic Stress-Induced Ileal Oxidative Stress and Apoptosis in Rats by Influencing Intestinal Flora and Activating Nrf2 Pathway

Wenjing Jiao, Haoyang Tan, Xin Cheng, Tianyuan Yang et autres

Background: Chronic stress is implicated in the pathogenesis of gastrointestinal disorders, with reactive oxygen species (ROS) contributing significantly. Chlorogenic acid (CGA), a polyphenolic compound, exhibits antioxidant properties. This study investigated whether CGA mitigates ROS-mediated oxidative stress and apoptosis in chronic stress-induced ileal …

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Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics

Huijuan Zhao, Jiteng Fan, Jing Han, Wenjun Qin et autres

Immunoglobulin G (IgG) N-glycans are associated with aging. In this study, we introduce a novel strategy for discovering aging-associated IgG glycans and establish a prediction model on the basis of their absolute concentration alterations. We employed glycomic quantification technology to identify alterations …

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Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics

Huijuan Zhao, Jiteng Fan, Jing Han, Wenjun Qin et autres

Abstract Immunoglobulin G (IgG) N-glycans have been identified as associated with aging; however, previous studies predominantly quantified changes based on the relative percentages of each glycan within the total glycan pool, neglecting the absolute concentration changes of individual glycans. Additionally, relative quantification …

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Chlorogenic Acid Alleviates Chronic Stress-Induced Intestinal Damage by Inhibiting the P38MAPK/NF-κB Pathway

Yuan Zhao, Chaoran Wang, Tianyuan Yang, Guofeng Feng et autres

Chronic stress can cause intestinal barrier damage. MAPK and NF-κB are closely related to it. Chlorogenic acid (CGA), a dietary polyphenol, has been shown to have intestinal protective effects, but whether by regulating MAPK and NF-κB is not known. Therefore, in this …

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Generalized low levels of serum N‐glycans associate with better health status

Jiteng Fan, Jichen Sha, Shuwai Chang, Huijuan Zhao et autres

Caloric restriction (CR) can prolong life and ameliorate age-related diseases; thus, its molecular basis might provide new insights for finding biomarker and intervention for aging and age-related disease. Glycosylation is an important post-translational modification, which can timely reflect the changes of intracellular …

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α2,3-Sialylation with Fucosylation Associated with More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive Interstitial Lung Disease

Rongrong Zhang, Jichen Sha, Shuwai Chang, Jiangfeng Zhao et autres

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Serum IgG N‐glycans enable early detection and early relapse prediction of colorectal cancer

Yong Gu, Bensong Duan, Jichen Sha, Rongrong Zhang et autres

Colorectal cancer (CRC) develops mainly from colorectal advanced adenomas (AA), which are considered precancerous lesions. Novel early diagnostic biomarkers are urgently needed to distinguish CRC and AA from healthy control (HC). Alternative glycosylation of serum IgG has been shown to be closely …

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B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice

Jichen Sha, Jiteng Fan, Rongrong Zhang, Yong Gu et autres

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The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma

Jichen Sha, Rongrong Zhang, Jiteng Fan, Yong Gu et autres

Serum immunoglobulin G (IgG) glycosylation, especially galactosylation, has been found to be related to a variety of tumors, including hepatocellular carcinoma (HCC). However, whether IgG glycan changes occur in the early stages of HCC formation remains unclear. We found that the galactosylation …

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α2,3-Sialylation With Fucosylation Associated With More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive Interstitial Lung Disease

Rongrong Zhang, Li Guo, Jichen Sha, Shuwai Chang et autres

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