Cecilia Battistelli

Interplay between the RBP SYNCRIP and RNA methylation in determining sEV miRNA-cargo and function in cell-to-cell communication

Luca Quattrocchi, Sabrina Garbo, Francesco Marocco, Maria Matilde Renne et autres

Small extracellular vesicles (sEVs) are critical mediators of tumor microenvironment communication, largely through the selective transfer of microRNAs (miRNAs) that reprogram recipient cells. Active miRNA sorting into sEVs depends on RNA‑binding proteins (RBPs), sequence determinants, and RNA modifications. Here, a functional interplay …

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Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity

Veronica Bordoni, Federica Guarracino, Francesco Marocco, Luca Quattrocchi et autres

BACKGROUND: Vδ2 T cells are promising candidates for approaches of immunotherapy due to their unique pleiotropic functions; they were recently shown to enhance antiviral protection in hematopoietic stem cell transplantation (HSCT) recipients via innate effector activity and modulation of virus-specific adaptive T-cell …

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Additional file 1 of Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity

Veronica Bordoni, Federica Guarracino, Francesco Marocco, Luca Quattrocchi et autres

Supplementary Material 1

it, jp (code pays fourni par la source)

Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity

Veronica Bordoni, Federica Guarracino, Francesco Marocco, Luca Quattrocchi et autres

Abstract Background Vδ2 T cells are promising candidates for approaches of immunotherapy due to their unique pleiotropic functions; they were recently shown to enhance antiviral protection in hematopoietic stem cell transplantation (HSCT) recipients via innate effector activity and modulation of virus-specific adaptive …

it, jp (code pays fourni par la source)

Additional file 1 of Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity

Veronica Bordoni, Federica Guarracino, Francesco Marocco, Luca Quattrocchi et autres

Supplementary Material 1

it, jp (code pays fourni par la source)

Extracellular vesicles from activated Vδ2 T cells inhibit viral replication and enhance adaptive antiviral immunity

Veronica Bordoni, Federica Guarracino, Francesco Marocco, Luca Quattrocchi et autres

Abstract Background Vδ2 T cells are promising candidates for approaches of immunotherapy due to their unique pleiotropic functions; they were recently shown to enhance antiviral protection in hematopoietic stem cell transplantation (HSCT) recipients via innate effector activity and modulation of virus-specific adaptive …

it, jp (code pays fourni par la source)

HOTAIR requires epitranscriptomic modification to exert its pivotal epigenetic role in Epithelial to Mesenchymal Transition

Sabrina Garbo, Francesco Marocco, Iris Di Silverio, Giulio Bontempi et autres

While m6A epitranscriptomic modification has been shown to impact several mRNAs maturation, stability/degradation, nuclear/cytoplasm export and translation regulation, its impact on lncRNAs activity is yet largely uncharacterized. Here, we show that the silencing of the m6A writer METTL3 inhibits Epithelial to Mesenchymal …

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Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch

Giulio Bontempi, Federica Michetti, Michela Terri, Cecilia Battistelli et autres

Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in pro-inflammatory conditions, including peritoneal dialysis (PD), a renal replacement therapy. Characteristic of this process is the acquisition of invasive/pro-fibrotic abilities by mesothelial cells (MCs) through induction of mesothelial to mesenchymal …

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Beyond Antibodies: Reinventing Alzheimer’s Treatment for the Next Decade

Sabrina Garbo, Alessia Raucci, Clemens Zwergel, Jadwiga Handzlik et autres

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Author response: Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

This article makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs.The findings are convincing and advance our understanding of RNA-binding proteinmediated miRNA sorting, providing …

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Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …

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Author response: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …