Micky Daniel Tortorella

Author's reply to the Letters regarding “Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation”

Luxi Zheng, Zhengmeng Yang, Sihui Chen, Gongli Cai et autres

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Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation

Luxi Zheng, Zhengmeng Yang, Sihui Chen, Gongli Cai et autres

Objective Osteoarthritis (OA) was traditionally viewed as a mechanically driven disorder. However, emerging evidence implicated metabolic dysregulation in its pathogenesis. This study investigated the novel interaction among cysteine metabolism, ferroptosis, and OA progression, while evaluating the therapeutic efficacy of L-cysteine supplementation. Methods …

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Synthesis and Biological Evaluation of Thiazolyl-Benzene/Camphor Sulfonamide Derivatives as Antibacterial, Antioxidant, and Antidiabetic Compounds

Sreenivas Avula, Satish Koppireddi, Micky Daniel Tortorella, Cléopatra Neagoie

Thiazolyl-benzene/camphor sulfonamide derivatives (series 4a–k, 5a–j and 6a–i) were synthesized by reaction of various aryl sulfonyl chlorides and camphor sulfonyl chlorides with 2-amino-4-phenylthiazole. The compounds were evaluated for antibacterial, antioxidant, and α-glucosidase/α-amylase inhibitory activities. Biological screening showed that 4h, 5g and 5i …

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FOXA1 preserves cell polarity and restrains lysosome biogenesis in non-small cell lung adenocarcinoma

Xuecong Wang, B.G Zhang, Chu Sun, Meiyu Huang et autres

Abstract Background This study investigates the role of the pioneer transcription factor FOXA1 as a master gene in sustaining epithelial cell polarization in early-stage lung adenocarcinoma. The partial loss of FOXA1 is explored to determine if it will affect plasticity and progression …

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Entorhinal Cholecystokinin in Alzheimer’s Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model

Yixuan Sui, Nan Zhang, Xi Chen, Micky Daniel Tortorella

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. The entorhinal cortex (Ent) is among the earliest affected regions, and its neuropeptide cholecystokinin (CCK) supports neocortical-associated memory. Although our previous work demonstrated that CCK treatment rescues cognition and neuroplasticity …

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Discovery and Optimization of 4-Aminopteridin-7(8 H )-one Derivatives as Potent and Selective mTOR Inhibitors with Favorable Pharmacodynamic and Safety Characteristics

Danyang Wang, Gengwu Li, Jianxing Liu, Mengxin Li et autres

The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and a promising cancer therapeutic target. Using structure-guided design, we developed novel 4-aminopteridin-7(8 H )-one derivatives as ATP-competitive mTOR inhibitors. The lead compound T133 ( 51 ) demonstrated exceptional …

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Synthesis, Antimicrobial and Antiproliferative Activity of 1-Trifluoromethylphenyl-3-(4-arylthiazol-2-yl)thioureas

Sreenivas Avula, Satish Koppireddi, Micky Daniel Tortorella, Cléopatra Neagoie

This study reports the exclusive and rapid synthesis of twenty-four derivatives of 1-((mono/bis)trifluoromethyl)phenyl-3-(4-arylthiazol-2-yl)thioureas (series 7, 9 and 11), along with their antimicrobial activities against Candida albicans, Mycobacterium smegmatis and seven additional bacterial strains. The anticancer potential of these compounds was evaluated against …

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Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential

Minjing Ke, Yuanyue Shan, Ziwei Zhai, Guoqiang Yao et autres

Phospholipids in cell membrane provide both regulatory and structural function of a cell. How lipid remodeling regulates cell fate remains less explored. Here we report the cryo-electron microscopy structure of TMEM164 identified by genome-wide CRISPR screen as an anti-ferroptotic factor. The overall …

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Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes

Nan Hou, Zhengmeng Yang, Xuan Lu, Shanshan Bai et autres

Exposure to microgravity decreases bone volume and increases marrow fat, partly due to impaired BMSC osteogenesis and enhanced adipogenesis. Staphylococcal enterotoxin C2 (SEC2) can influence BMSC differentiation, potentially promoting osteogenesis. This study investigated SEC2's effects on bone loss and marrow fat in …

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Entorhinal cholecystokinin in Alzheimer’s disease: its earliest vulnerability and rescue effects across different disease stages

Yixuan Sui, Nan Zhang, Xi Chen, Micky Daniel Tortorella et autres

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DHA laden liposome incorporated HA-menthol-CD host-guest hydrogels as delivery system for osteoarthritis treatment

Zhengmeng Yang, Nan Hou, Boguang Yang, Yican Wang et autres

The immobilization of liposomes together laden drugs in the hydrogel matrix network has proven to be an effective technique for protecting them against rapid clearance in the body. This allows for localized and controlled drug delivery over a long period of time. …

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MiR-378 mediates the ovariectomy induced bone loss via exaggerating osteoclastogenesis and transforming growth factor beta impaired osteogenesis

Feng Lu, Zhengmeng Yang, Nan Hou, Haixing Wang et autres

Osteoporosis (OP) is a disease characterized by decreased bone mass and damaged architectures. The promising treatment strategy for OP is to inhibit bone resorption while promoting bone formation. MicroRNAs (miRNAs) have been shown to be associated with osteoclastogenesis and osteogenesis processes in …

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